… This is constitutively expressed on resting NK cells and induces NK activation after ligation …
monensin to the co-culture after 1 h to prevent internalization and degradation of the CD107a. …

… Natural Killer (NK) cells act as important regulators in the … against Multiple Myeloma (MM)
cells has been confirmed in many … NEDD8 ligase c-Cbl can neddylate TGFβ-RII, preventing its …

… , ULBP1, ULBP2, and ULBP6 to prevent their export to the cell surface by trapping them in
the … killing by the K5 viral product, an E3 ubiquitin ligase that reduces MICA levels at the cell …

… be elicited by other activating receptors but required the simultaneous ligation of multiple …
prevented NK cell activation but allowed for a more robust response against virus-infected …

… This study seeks to investigate how to prevent Treg cells’ suppression on NK killing of
cancer cells. The importance of this research is to further deepen the knowledge of the fight …

… ligation [29-32]. Later, a sophisticated model suggests that NK cell activation is a result of
competition between activating … somatic cells to prevent NK cells from destroying innocent cells. …

… human Cbl-b on tyrosine residues 133 and 363 [153]. Phosphorylation of Y363 prompts a
conformational change, activating Cbl-b E3 ubiquitin ligase … 3A), which would prevent MTOC …

… In human NK cells, inhibition of amino acid uptake through SLC1A5 and SLC7A5 prevented
IFNγ … IFNγ production and SLC3A2 expression following ligation of the activating receptor …

… with rituximab or ofatumumab could induce reactive oxygen species … NK cells and inducing
their apoptosis [226,227]. This effect can be prevented by treatment with idelalisib to prevent …

… that NKG2D ligation is the major activating signal for NK cells following IRI. … an activating
signal in the HC versus sham model. To determine if NKG2D ligation was the integral activating …