Light up ADHD: II. Neuropharmacological effects measured by near infrared spectroscopy: is there a biomarker?
S Grazioli, M Mauri, A Crippa, E Maggioni… - Journal of affective …, 2019 - Elsevier
Journal of affective disorders, 2019•Elsevier
Background Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental
disorder characterized by deficits in self-controlling attention, behavior, and emotions. In
recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS),
have been used to measure the neural correlates of pharmacological-therapy outcomes in
children and adolescents with ADHD. Methods We reviewed a short series of articles that
investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review …
disorder characterized by deficits in self-controlling attention, behavior, and emotions. In
recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS),
have been used to measure the neural correlates of pharmacological-therapy outcomes in
children and adolescents with ADHD. Methods We reviewed a short series of articles that
investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review …
Background
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in self-controlling attention, behavior, and emotions. In recent years, noninvasive optical techniques, such as near infrared spectroscopy (NIRS), have been used to measure the neural correlates of pharmacological-therapy outcomes in children and adolescents with ADHD.
Methods
We reviewed a short series of articles that investigated the results of functional NIRS (fNIRS) on developmental-age ADHD. The review was limited to fNIRS studies that investigated the cortical responses that occurred during neuropsychological tasks in ADHD patients who received methylphenidate or atomoxetine.
Results
The majority of the reviewed studies revealed the presence of increased oxygenated hemoglobin concentrations in the prefrontal cortex following pharmacotherapy in ADHD samples. A higher frequency of right-lateralized results was found.
Limitations
The considered studies are characterized by substantial methodological heterogeneity in terms of the patients’ medication status and washout period, explored cerebral regions, and neuropsychological tasks.
Conclusions
fNIRS seems to be a promising tool for the detection of pharmacological-treatment biomarkers in samples of children and adolescents with ADHD.
Elsevier
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