[HTML][HTML] Radioiodination of extravesicular surface constituents to study the biocorona, cell trafficking and storage stability of extracellular vesicles
SS Yerneni, T Solomon, J Smith… - Biochimica et Biophysica …, 2022 - Elsevier
… cell surface bound EVs prior to imaging the cells. At 37 C, PKH26-labeled EVs internalized
into cells … methodology remains relevant to evaluate any potential EV biocorona differences. …
into cells … methodology remains relevant to evaluate any potential EV biocorona differences. …
Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers
Y Feng, R Meshaw, D McDougald, Z Zhou, XG Zhao… - Scientific reports, 2022 - nature.com
… of the rationale for developing radiolabeled sdAbs for RPT … the ratio of internalized fraction
over surface bound fraction, … which has incorporated several distinguishing design features: a …
over surface bound fraction, … which has incorporated several distinguishing design features: a …
[HTML][HTML] Targeted photoimmunotherapy based on photosensitizer-antibody conjugates for multiple myeloma treatment
WM Darwish, NA Bayoumi, HM El-Shershaby… - … of Photochemistry and …, 2020 - Elsevier
… bound) is usually utilized to identify the cellular uptake of … to injection with the radiolabelled
antibody. Eventually this has … the total cell binding capacity (internalized and surface bound) …
antibody. Eventually this has … the total cell binding capacity (internalized and surface bound) …
[HTML][HTML] ImmunoPET predicts response to Met-targeted radioligand therapy in models of pancreatic cancer resistant to Met kinase inhibitors
… (immunoPET) can identify targets for cell-signaling independent … Cell surface-bound radiotracer
was collected by cells … Internalized fraction was obtained after cell lysis with 1 M sodium …
was collected by cells … Internalized fraction was obtained after cell lysis with 1 M sodium …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
… of the adaptive immune system to recognize and neutralize … (169) After surface-bound
antibodies capture C1q, a cascade … to the internalization and elimination of antibodies should also …
antibodies capture C1q, a cascade … to the internalization and elimination of antibodies should also …
Discovery of a highly specific radiolabeled antibody targeting B-cell maturation antigen: Applications in PET imaging of multiple myeloma
J Ma, S Zhang, N Yang, J Shang, X Gao, J Chen… - European Journal of …, 2024 - Springer
… significant difference in the binding affinity of the BCMA antibody, … , the cell uptake (sum of
internalized and surface-bound … The limitation of this study is the use of a subcutaneous tumor …
internalized and surface-bound … The limitation of this study is the use of a subcutaneous tumor …
Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR× LGR5 bispecific antibody with efficacy in epithelial tumors
B Herpers, B Eppink, MI James, C Cortina… - Nature cancer, 2022 - nature.com
… 3d, blue surface) and overlap with the surface bound by EGF (Fig… -158 triggers EGFR
internalization and degradation in an … . The immunoreactivity of the antibody after radiolabeling …
internalization and degradation in an … . The immunoreactivity of the antibody after radiolabeling …
Screening and Preclinical Evaluation of Novel Radiolabeled Anti-Fibroblast Activation Protein-α Recombinant Antibodies
J Xu, S Li, S Xu, J Dai, Z Luo, J Cui, F Cai… - Cancer Biotherapy & …, 2023 - liebertpub.com
… FAPα, which is a cell surface-bound type II transmembrane … analysis, except a slight difference
between the uptake values of … with no internalization that limits their function for efficient …
between the uptake values of … with no internalization that limits their function for efficient …
Translational development of a Zr-89-labeled inhibitor of prostate-specific membrane antigen for PET imaging in prostate cancer
SM Vázquez, H Endepols, T Fischer… - Molecular Imaging and …, 2022 - Springer
… The only difference lies in the chelating agent for zirconium … radiolabeling procedure was
performed by adjusting the pH of … glycine (surface-bound), and 1 M NaOH (internalized fraction) …
performed by adjusting the pH of … glycine (surface-bound), and 1 M NaOH (internalized fraction) …
Validation of Dual-Action Chemo-Radio-Labeled Nanocarriers with High Efficacy against Triple-Negative Breast Cancer
S Ilyas, S EM Sahnoun, A Szymura, J Pes… - … applied materials & …, 2023 - ACS Publications
… conditions to avoid the loss of surface-bound molecules. The … only by internalized
nanocarriers, the cell supernatants were … We utilized a ROUT test to identify outliers. In case of …
nanocarriers, the cell supernatants were … We utilized a ROUT test to identify outliers. In case of …