… shown to involve Cdc50, the regulatory subunit of lipid flippase. In … neoformans virulence in
murine infection models (31). … Cdc50-mediated drug resistance, we screened for caspofungin-…

… Cdc50 is the non-catalytic subunit of the flippase that establishes phospholipid asymmetry
in membranes and functions in vesicle-mediated … studied in Cryptococcus neoformans (Hu …

… neoformans is finely regulated to promote fungal virulence, … with their respective Cdc50
subunits have revealed the … and can mediate transport of a broader range of lipid substrates. Of …

… Mutants with a deleted subunit of lipid flippase, Cdc50, showed … responsible for the apparent
drug resistance and, additionally, … to its disruption of Cdc50 mediated lipid flippase function. …

… glabrata, and thus have a broad influence on drug susceptibility and virulence. This work …
in Cryptococcus neoformans. Furthermore, Cdc50 was reported to mediate azole susceptibility, …

… recently associated with virulence and drug resistance in many … P4 ATPases only mediate
inward-oriented transport of lipids, … depleted of the flippase β-subunit Cdc50 display defects in …

… drug resistance in fungi. The encapsulated fungal pathogen … , we tested their lipid flippase
activity in comparison to Apt1p … neoformans Cdc50 as an essential subunit for Apt1-3p and …

… of lipid flippase inhibitors and investigating their potential as antimicrobial agents against
various drug resistant … Cryptococcus neoformans (Cn) is a drug resistant pathogenic fungus …

… α subunit (P4-ATPase) and accessory β subunit [Cdc50/Lem3/… The P4-ATPase Apt1-Cdc50
from Cryptococcus neoformans … Also, CaCdc50 plays a vital role in antifungal drug resistance…

… pathways known for mediating drug resistance and immune … unit of flippase known as
Cdc50 has been studied in C. … With the growing appreciation of the emerging role of lipids in …