[PDF][PDF] Manipulation of lipid metabolism during normothermic machine perfusion: effect of defatting therapies on donor liver functional recovery

YL Boteon, J Attard, APCS Boteon… - Liver …, 2019 - Wiley Online Library
… pharmacological enhancement of the lipid metabolism of human livers during ex situ … Lipid
metabolism and functional assessment of discarded human livers with steatosis undergoing

Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

L Aoudjehane, J Gautheron, W Le Goff… - Disease models & …, 2020 - journals.biologists.com
… Indeed, we found that CHOP and GADD34 underwent a significant downregulation in their
… Although steatotic livers already make up a major proportion of discarded livers, we predict …

Use of machine perfusion in livers showing steatosis prior to transplantation: a systematic review

Q Lai, F Ruberto, TM Pawlik, F Pugliese, M Rossi - Updates in Surgery, 2020 - Springer
human livers discarded and not transplanted after perfusion; c) lacked sufficient details
on the biopsy-proven steatosis … % of organs with more advanced MaS underwent an HMP/HOPE …

Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies

S Raigani, N Karimian, V Huang, AM Zhang, I Beijert… - PloS one, 2020 - journals.plos.org
… , efficient energy utilization, and lipid metabolism. Steatotic … for oxidation while still being
insufficient for the degree of steatosis [… donors whose discarded liver was included in this study. …

[PDF][PDF] Banff consensus recommendations for steatosis assessment in donor livers

DAH Neil, M Minervini, ML Smith, SG Hubscher… - …, 2022 - Wiley Online Library
… uniformity in the assessment of donor steatosis. Donor livers discarded as being unsuitable
… deemed suitable for transplantation who subsequently underwent transplantation did well …

[HTML][HTML] NRF2 assessment in discarded liver allografts: A role in allograft function and salvage

O Ahmed, M Xu, F Zhou, AN Wein, GA Upadhya… - American Journal of …, 2022 - Elsevier
… , we used a rat fatty-liver model, treating livers with an NRF2 … livers underwent further injury
and remained unsuitable for clinical use (unfilled red arrow). Lower panel: Hepatic steatosis

Steatosis in liver transplantation: current limitations and future strategies

I Linares, M Hamar, N Selzner, M Selzner - Transplantation, 2019 - journals.lww.com
… [FGF]-19 and -21, lipid metabolism, intestinal transporters, intestinal microbiota, and endocrine
… , functional, and hemodynamic characterization of discarded human fatty livers during …

Mesenchymal stem cells ameliorate lipid metabolism through reducing mitochondrial damage of hepatocytes in the treatment of post-hepatectomy liver failure

J Wang, H Ding, C Pan, X Shi, H Ren - Cell Death & Disease, 2021 - nature.com
… After 24 h of incubation, unattached cells were discarded, … in the remaining liver of rats
undergoing hepatectomy and … by MSCs can affect liver steatosis induced by hepatectomy. IL-10 …

Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice

JM Weiss, EM Palmieri, M Gonzalez-Cotto… - … Metabolism, 2023 - nature.com
liver macrophages in a mouse model of NAFLD and human … Alb Cre mice that have the gene
deleted in hepatocytes (Fig. 2b)… recruited macrophages undergo reprogramming in the liver

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

D Patrono, R De Carlis, A Gambella… - Liver …, 2023 - journals.lww.com
liver grafts having initially been discarded for liver transplantation (LT). However, its results in
the setting of significant (≥30%) macrovesicular steatosis (… cannulation, livers underwent a …