[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic
trait largely controlled by one single gene (LPA) that contains a complex interplay of several
genetic elements with many surprising effects discussed in this review. A hypervariable
coding copy number variation (the kringle IV type-2 repeat, KIV-2) generates> 40
apolipoprotein (a) protein isoforms and determines the median Lp (a) concentrations …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic
trait largely controlled by one single gene (LPA) that contains a complex interplay of several
genetic elements with many surprising effects discussed in this review. A hypervariable
coding copy number variation (the kringle IV type-2 repeat, KIV-2) generates> 40
apolipoprotein (a) protein isoforms and determines the median Lp (a) concentrations …
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