MEG3: an oncogenic long non-coding RNA in different cancers

A Al-Rugeebah, M Alanazi, NR Parine - Pathology & Oncology Research, 2019 - Springer
… might affect the cellular functions to develop cancer cells, for … of MEG3 to inhibit angiogenesis,
and alternations of MEG3 in … suppressor genes, therefore, induced apoptosis. Notably, Rb …

[HTML][HTML] The functional role of long non-coding RNAs and their underlying mechanisms in drug resistance of non-small cell lung cancer

H Zhou, B Feng, M Abudoureyimu, Y Lai, X Lin, C Tian… - Life sciences, 2020 - Elsevier
… (PUMA) -induced apoptosis while silencing SNHG12 can … LncRNA MEG3 expression
is lower in lung cancer tissues than … LncRNAs affect the sensitivity of NSCLC cells to …

[HTML][HTML] Long noncoding RNA MEG3 inhibits cell migration and invasion of non‑small cell lung cancer cells by regulating the miR‑21‑5p/PTEN axis

D Lv, Q Bi, Y Li, J Deng, N Wu… - Molecular medicine …, 2021 - spandidos-publications.com
… tissues and cell lines, and that low MEG3 expression levels are … MEG3 overexpression can
inhibit cell proliferation, promote apoptosis and enhance chemotherapy sensitivity in NSCLC

[HTML][HTML] Long non-coding RNA MEG3 regulates migration and invasion of lung cancer stem cells via miR-650/SLC34A2 axis

Y Zhao, Z Zhu, S Shi, J Wang, N Li - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… miR-650 inhibitor alleviated si-MEG3-induced promotion of stem cell-like characteristics in
… of MEG3 on stem cell-like state and metastasis in NSCLC cells and explore the role of MEG3/…

[HTML][HTML] Long noncoding RNA MEG3 suppresses gastric carcinoma cell growth, invasion and migration via EMT regulation

J Jiao, S Zhang - Molecular Medicine Reports, 2019 - spandidos-publications.com
… of lncRNA-MEG3 was able to affect gastric tumor growth … cells through the induction of cell
cycle arrest and apoptosis (36). It may also inhibit non-small cell lung cancer cell proliferation

[HTML][HTML] The biological roles and molecular mechanisms of long non-coding RNA MEG3 in the hallmarks of cancer

L Zhang, F Zhao, W Li, G Song, V Kasim, S Wu - Cancers, 2022 - mdpi.com
MEG3 affects the stability of proteins by regulating their post-… MEG3 could inhibit the
growth and proliferation of T-cellMEG3 can also enhance NSCLC sensitivity to cisplatin by …

Long noncoding RNA MEG3 suppresses cell proliferation, migration and invasion, induces apoptosis and paclitaxel-resistance via miR-4513/PBLD axis in breast …

M Zhu, F Wang, H Mi, L Li, J Wang, M Han, Y Gu - Cell Cycle, 2020 - Taylor & Francis
… that long non-coding RNA maternally expressed 3 (MEG3) … , such as lncRNAs can affect the
phenotypes of diverse cancers via … in numerous tumors, such as lung cancer [Citation31] and …

[HTML][HTML] Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA

S Ghafouri-Fard, M Taheri - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… protein levels of p53 without affecting its transcript levels, it … inhibited cells growth and
metastasis and induced apoptosis … In non-small cell lung cancer cells, MEG3 increases cisplatin …

Long non-coding RNA in lung cancer

Z Chen, T Lei, X Chen, J Gu, J Huang, B Lu, Z Wang - Clinica chimica acta, 2020 - Elsevier
inhibited lung cancer cell proliferation and induced apoptosis. … of MEG3 after paclitaxel
treatment of A549 cells; the MEG3-P53 … cells, but did not affect proliferation. Furthermore, lung …

[HTML][HTML] … : Long non-coding RNA MEG3 inhibits cell proliferation, migration, invasion and enhances apoptosis in non-small cell lung cancer cells by regulating the miR …

K Li, X Wang, Z Huang, H Xu, S Zheng, Y Qiu - RSC advances, 2019 - pubs.rsc.org
… 31-5p could affect NSCLC cell development through regulation … MEG3 overexpression could
suppressed cell proliferation and induced apoptosis to impede the tumorigenesis of NSCLC