[HTML][HTML] Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high …

JR Turk, AM Deaton, J Yin, M Stolina, M Felx… - Regulatory Toxicology …, 2020 - Elsevier
inhibited AngII-induced aortic aneurysm and atherosclerosis, … Distal left anterior descending
coronary artery and side … and monkey heart nor in tissue-associated vascular beds. …

[HTML][HTML] Bias in animal studies of estrogen effects on cardiovascular disease: A systematic review and meta‐analysis

CF Berntsen, P Rootwelt, AEA Dahm - Research and practice in thrombosis …, 2021 - Elsevier
… , especially when it was started shortly after menopause, while others put more confidence
… for cynomolgus monkeys suggests a small protective effect of estrogens on atherosclerosis is …

Mechanisms of increased vascular stiffness down the aortic tree in aging, premenopausal female monkeys

D Babici, RK Kudej, T McNulty… - … Physiology-Heart …, 2020 - journals.physiology.org
… that estrogen replacement in old women results in a lower … –40 yr and undergo menopause
similar to that observed in … activity in old monkeys, with no change in tissue inhibitor of MMP (…

Estradiol replacement timing and obesogenic diet effects on body composition and metabolism in postmenopausal macaques

JQ Purnell, HF Urbanski, P Kievit, CT Roberts Jr… - …, 2019 - academic.oup.com
… women, the postmenopausal hormonal decline of estrogen (E… of significant reductions in
cardiovascular disease events (21… In comparison, a typical regular monkey chow formulation (ie…

Menopausal hormone therapy and coronary heart disease: the roller-coaster history

M Nudy, J Buerger, S Dreibelbis, X Jiang, HN Hodis… - …, 2024 - Taylor & Francis
coronary heart disease death) in the Heart and Estrogen/… coronary artery atherosclerosis
compared to control. When cynomolgus monkeys initiated HT soon after surgical menopause

[HTML][HTML] Estrogen receptor and vascular aging

M Davezac, M Buscato, R Zahreddine, P Lacolley… - Frontiers in …, 2021 - frontiersin.org
estrogen deprivation due to menopause contributes to arterial aging and increase of
cardiovascular disease … was conducted in female monkeys in which atherosclerosis extent was …

[HTML][HTML] The effects of estrogen and hormone replacement therapy on platelet activity: A review

M Hashemzadeh, F Haseefa, L Peyton… - American Journal of …, 2022 - ncbi.nlm.nih.gov
… In addition, the likelihood of coronary artery atherosclerosis in male versus female … monkeys
had less atherosclerosis and a lower incidence of thrombosis. Postmenopausal monkeys

The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women: a systematic review

C Oliver-Williams, M Glisic, S Shahzad… - Human reproduction …, 2019 - academic.oup.com
… of heart disease, reported a 30% lower risk of coronary heart disease (CHD) for women using
estrogen alone or … Also, low doses of CEE in monkeys were associated with a reduction in …

[HTML][HTML] Cardiovascular health and the menopausal woman: the role of estrogen and when to begin and end hormone treatment

F Naftolin, J Friedenthal, R Nachtigall… - F1000Research, 2019 - ncbi.nlm.nih.gov
… of menopause is fundamental to the success of estrogen’s … estrogen may protect against
cardiovascular disease (CVD). … estrogen does not remove plaque; when he treated monkeys

Dietary soy phytoestrogens and the health of menopausal women: overview and evidence of cardioprotection from studies in non-human primates

CL Hughes, JM Cline, JK Williams… - … of the Menopause …, 2020 - taylorfrancis.com
estrogen agonists/antagonists in the cardio vascular system … coronary arteries to
acetylcholineliO and reduce aortic … • In a third study (in this instance in young male monkeys), we …