Catalytically inactive DNA ligase IV promotes DNA repair in living cells
NJ Goff, M Brenière, CJ Buehl, AJ de Melo… - Nucleic Acids …, 2022 - academic.oup.com
… this short-range NHEJ complex requires DNA ligase IV (Lig4), … Lig4 complex promotes the
activity of DNA ligase III (Lig3). … of the ligase complex (but not its ligase activity) is sufficient to …
activity of DNA ligase III (Lig3). … of the ligase complex (but not its ligase activity) is sufficient to …
The molecular basis and disease relevance of non-homologous DNA end joining
B Zhao, E Rothenberg, DA Ramsden… - … Reviews Molecular Cell …, 2020 - nature.com
… NHEJ proteins directly or indirectly (Fig. 1). Direct ligation of the DNA ends is performed by
the XRCC4–DNA ligase 4 (… two DNA ends together suggests this enzyme is also sufficient to …
the XRCC4–DNA ligase 4 (… two DNA ends together suggests this enzyme is also sufficient to …
Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity
JR McNally, AM Ames, SJ Admiraal… - Nucleic Acids …, 2023 - academic.oup.com
… DNA ligases III and IV (LIG3, LIG4) have long been credited … by 14 bp of duplex DNA were
found to be of sufficient length, … reaction reached saturation at low concentrations of the 3′-…
found to be of sufficient length, … reaction reached saturation at low concentrations of the 3′-…
[HTML][HTML] Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining
BM Stinson, SM Carney, JC Walter… - Nature Communications, 2024 - nature.com
… interactions of the NHEJ-specific DNA Ligase IV (Lig4) within … Ku and DNA-PKcs are sufficient
for LR complex formation, but other … For this purpose, we developed a three-color single-…
for LR complex formation, but other … For this purpose, we developed a three-color single-…
Altered DNA ligase activity in human disease
AE Tomkinson, T Naila, S Khattri Bhandari - Mutagenesis, 2020 - academic.oup.com
… have lower levels of mitochondrial DNA ligase IIIα, … NHEJ proteins including DNA PKcs
and DNA ligase IV/XRCC4. While these three core components are sufficient to join duplex DNA …
and DNA ligase IV/XRCC4. While these three core components are sufficient to join duplex DNA …
Stress-inducible NHEJ in bacteria: function in DNA repair and acquisition of heterologous DNA
… Here, we show that Ku2 is enough to achieve the main NHEJ … are the actual NHEJ ligases
working with Ku2 and Ku3–4, … DNA bridging, DNA threading and recruitment of DNA ligase …
working with Ku2 and Ku3–4, … DNA bridging, DNA threading and recruitment of DNA ligase …
[HTML][HTML] Alternative non-homologous end-joining: error-prone DNA repair as cancer's achilles' heel
… synthesis, which generates sufficiently long de novo microhomologies … levels of core C-NHEJ
components such as Artemis and DNA ligase IV were downregulated while DNA ligase III …
components such as Artemis and DNA ligase IV were downregulated while DNA ligase III …
Structural basis of long-range to short-range synaptic transition in NHEJ
… DNA-dependent protein kinase (DNA-PKcs), DNA ligase IV (… Third, we identified two
conserved loops in the middle HEAT … The resolution of the linker loop was not good enough to …
conserved loops in the middle HEAT … The resolution of the linker loop was not good enough to …
[HTML][HTML] The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
… plus XRCC4:DNA ligase IV are necessary and sufficient to … Moreover, we would expect a
higher transition rate from low E … , we propose that up to three XLF dimers at the DNA ends may …
higher transition rate from low E … , we propose that up to three XLF dimers at the DNA ends may …
Repair of DNA double-strand breaks by the nonhomologous end joining pathway
BM Stinson, JJ Loparo - Annual review of biochemistry, 2021 - annualreviews.org
… end joining (NHEJ), which pairs DNA ends in a multiprotein … Ultimately, DNA ligase IV (LIG4),
which forms a constitutive … (80), supporting the idea that sufficient XLF tail length appears to …
which forms a constitutive … (80), supporting the idea that sufficient XLF tail length appears to …