Epidermal growth factor receptor tyrosine kinase inhibitors for non‐small cell lung cancer harboring uncommon EGFR mutations: Real‐world data from Taiwan

JWC Chang, CY Huang, YF Fang, CF Chang… - … Cancer, 2023 - Wiley Online Library
mutations and the poor response observed for exon 20gefitinib/erlotinib. Although most
EGFR-TKIs were not effective for exon 20 insertions, some patients benefited from treatment

Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions

NJ Choudhury, AJ Schoenfeld, J Flynn, CJ Falcon… - Clinical Cancer …, 2021 - AACR
… The suboptimal response to ICI observed among … poor activity in patients with NSCLC with
driver alterations. A series of EGFR-mutant lung cancers previously reported poor responses

Successful treatment of lung adenocarcinoma with epidermal growth factor receptor compound mutations involving exon 19 deletion and exon 20 insertion by afatinib

T Ikeuchi, H Tokuyasu, S Ishikawa - Internal Medicine, 2019 - jstage.jst.go.jp
… A good response to afatinib was evident in our patient who had lungLung cancer with
epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment

… epidermal growth factor receptor tyrosine kinase inhibitors treatment and EGFR exon 19 deletion with frequency of the T790M mutation in non-small cell lung cancer …

W Gao, J He, SD Jin, J Xu, TF Yu, W Wang… - … and therapy, 2019 - Taylor & Francis
… who received gefitinib as a previous EGFR-TKI treatment had a … as well as the use of
low-sensitivity detection methods (false … a partial response to previous EGFR-TKI treatment had a …

[HTML][HTML] … responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with uncommon EGFR mutations: new insights and future …

A Russo, T Franchina, G Ricciardi, A Battaglia… - International Journal of …, 2019 - mdpi.com
… subgroup of Non-Small Cell Lung Cancers (NSCLCs), that … treated with gefitinib [41],
though they may better respond to … Human epidermal growth factor receptor 2 (HER2) exon 20-…

[HTML][HTML] Clinical characteristics of advanced non-small cell lung cancer patients with EGFR exon 20 insertions

C Morita, T Yoshida, M Shirasawa, K Masuda… - Scientific reports, 2021 - nature.com
Epidermal growth factor receptor (EGFR) exon 20 insertion … with these EGFR mutations
respond to treatment with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) such as gefitinib, erlotinib…

[HTML][HTML] Co-occurring alterations of ERBB2 exon 20 insertion in Non-Small Cell Lung Cancer (NSCLC) and the potential indicator of response to afatinib

B Yuan, J Zhao, C Zhou, X Wang, B Zhu, M Zhuo… - Frontiers in …, 2020 - frontiersin.org
epidermal growth factor receptor 2 (ERBB2, HER-2) exon 20 … it is probably caused by the
low detection rate of CNV due to … induced upon treatment with erlotinib or gefitinib (39, 40) and …

[HTML][HTML] Epidermal growth factor receptor expression and resistance patterns to targeted therapy in non-small cell lung cancer: A review

EA Karlsen, S Kahler, J Tefay, SR Joseph, F Simpson - Cells, 2021 - mdpi.com
mutations were related to the sensitivity of NSCLC to gefitinib, … that predicted poor outcomes
and poor response to therapy [… or afatinib for the treatment of exon 20 insertion tumours have …

[HTML][HTML] Concurrent driver gene mutations as negative predictive factors in epidermal growth factor receptor-positive non-small cell lung cancer

M Chen, Y Xu, J Zhao, W Zhong, L Zhang, Y Bi… - …, 2019 - thelancet.com
… -cell lung cancer to gefitinib. … response to treatment and epidermal growth factor receptor
tyrosine kinase inhibitors in patients with EGFR-mutant advanced non-small cell lung cancer. …

[HTML][HTML] EGFR exon 20 insertion in metastatic non-small-cell lung cancer: survival and clinical efficacy of EGFR tyrosine-kinase inhibitor and chemotherapy

S Chelabi, X Mignard, K Leroy, I Monnet, S Brosseau… - Cancers, 2021 - mdpi.com
… There was no significant difference in the tumor response or … Epidermal growth factor
receptor (EGFR) mutations, mainly … to standard TKIs (erlotinib, gefitinib, afatinib), and their …