… , the astray in antibacterial drug discovery and development. Our … -like compounds and often
violate desirable parameters for … This work was supported in part by Leahi Fund to Treat and …

… compounds could simultaneously act on two or more targets in bacteria [24, 25]. Accordingly,
the rational design of macrolide hybrids … of actions to facilitate further rational drug design. …

… of existing anti-inflammatory FDA-approved drugs by the … drug repurposing of ribavirin for
anti-infective therapy [113]. … isolates that were constitutively resistant to macrolides (MIC50/90, 2…

… to possess some anti-inflammatory activity both in vitro and in vivo. Indeed, macrolides could
… Interestingly, because of these anti-inflammatory properties, macrolide antibiotics have …

… mechanism needed for antitubercular drug design…” [106]. … demonstrated that the polycyclic
macrolide sporolide B (129) … , and thus “could be a possible drug candidate for HIV” [125]. …

… to penicillins and macrolides, including Streptococcus … cells, antiinflammatory activity, a low
incidence of drug resistance … out of this work and currently this compound is under phase II …

… in anti-TB drug discovery and development, relative to both … of other compound moieties (of
interest to TB drug development) (… avenues for synthesizing potential new anti-TB lead drugs. …

… Drug repurposing is an emerging field in drug discovery that … , anti-helminthic drug,
niclosamide, and macrolide antibiotic, … ), a lipid-lowering drug with antioxidant and anti-inflammatory …

… Antibiotic macrolides are experiencing renewed interest in anti-infective therapy since the …
-antibacterial activities, in particular immunomodulatory and anti-inflammatory properties [7] [8]…

… drug discovery. As such, the availability of research funds for the development of new
compounds is … Unlike COVID-19, we have the opportunity to plan ahead and remain on top of any …