Mangiferin promotes osteogenic differentiation and alleviates osteoporosis in the ovariectomized mouse via the AXL/ERK5 pathway

J He, X Wang, D Zhao, B Geng, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
… by Mangiferin. Mangiferin relieved osteoporosis in OVX mice without causing severe organ
damage. This study concluded that Mangiferin promoted osteogenic differentiation of MC3T3-…

Mangiferin promotes the osteogenic differentiation of human periodontal ligament stem cells via TGF‑β/SMAD2 signaling

Y Gu, L Zhang, Y Bai - Molecular Medicine Reports, 2022 - spandidos-publications.com
Mangiferin (MAG) is a polyphenolic compound present in mangoes. This compound suppresses
inflammation and decreases bone destruction. This study aimed to determine whether …

Er-xian decoction drug-containing serum promotes Mc3t3-e1 cell proliferation and osteogenic differentiation via regulating BK channel

MS Ren, HH Xie, Y Ding, ZH Li, B Liu - Journal of Ethnopharmacology, 2023 - Elsevier
… BMP2 promotes osteoblast differentiation by … Mangiferin has the potential to promote
osteoblastic bone formation by promoting cell proliferation and inducing cell differentiation in …

Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells

S Sharifi, FA Moghaddam, A Abedi, S Maleki Dizaj… - …, 2020 - Wiley Online Library
… elements that boost osteoblastic differentiation. Runx2 particularly is bonded to the Osx
promoter section regulating osteoblast differentiation in vitro and in vivo, also regulates Osx, …

CpG ODN/Mangiferin Dual Delivery through Calcium Alginate Hydrogels Inhibits Immune-Mediated Osteoclastogenesis and Promotes Alveolar Bone Regeneration in …

Y Gu, Y Hu, S Huang, S Ruiz, T Kawai, Y Bai, X Han - Biology, 2023 - mdpi.com
… This is consistent with the reports by others showing that mangiferin positively regulates
osteoblast differentiation and suppresses osteoclastogenesis, bone resorption, and RANKL-…

Mangiferin-Enriched Mn–Hydroxyapatite Coupled with β-TCP Scaffolds Simultaneously Exhibit Osteogenicity and Anti-Bacterial Efficacy

S Swain, JR Koduru, TR Rautray - Materials, 2023 - mdpi.com
… The synthesis of 5% and 10% Mn-doped BCP-MAN scaffolds has been carried out in this
investigation and the efficacy of mangiferin and manganese in terms of enhanced bone …

[PDF][PDF] The Mangiferin (Mangifera Indica Linn) Effect Against the Calcium Degradation, Bones Resorption and Ossification of Rattus novergicus of Post-orthodontic …

Y Alamsyah, S Ilyas, DP Putra - Journal of International Dental and …, 2020 - jidmr.com
… Whereas resorption is associated with the degradation of calcium as a process of bone
resorption in the form of minerals facilitated by osteoclasts.Therefore, the ability of mangiferin to …

[PDF][PDF] Garcinone C attenuates RANKL-induced osteoclast differentiation and oxidative stress by activating Nrf2/HO-1 and inhibiting the NF-kB signaling pathway

H Ji, Q Pan, R Cao, Y Li, Y Yang, S Chen, Y Gu, D Qian… - Heliyon, 2024 - cell.com
mangiferin, which has been reported to inhibit osteoclasts in 358 animals [40], and α-mangiferin
α-Mangiferin and Gar C are derivatives of the natural phenolic 360 antioxidant luteolin. α…

Effects of urolithin A on osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand via bone morphogenic protein 2

Z Wang, G Qi, Z Li, X Cui, S Guo, Y Zhang, P Cai… - …, 2022 - Taylor & Francis
mangiferin significantly reduces the formation of TRACP-positive multinuclear cells, which
indicates that mangiferin … Transcription factor RUNX2 is critical for osteoblast differentiation

Non-flavonoid polyphenols in osteoporosis: Preclinical evidence

D Bellavia, F Caradonna, E Dimarco, V Costa… - Trends in Endocrinology …, 2021 - cell.com
osteoblast differentiation and activities and inhibiting osteoclast differentiation and activities.
… osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. …