… Furthermore, siNrf2 was found to positively regulate the protein levels of CTSK, ATP6V0D2,
and NFTAc1 under TSG treatment (Fig. 7HI). This observation illustrated that TSG inhibits …

… We found that EEPL suppressed osteoclast differentiation by directly acting on osteoclast
precursor cells. EEPL suppressed the expression of receptor activator of nuclear factor-κB …

… apoptosis in osteoblast have been proposed. The osteoblast differentiation is inhibited by …
suppression of Wnt signaling.[ 19 20 21 ] Moreover, high dose of glucocorticoids elevates …

… ALP is an early phenotypic marker and an essential enzyme in osteoblast differentiation [29].
OCN is an important non-collagen component secreted by osteoblasts into the bone matrix …

… of mangiferin to mitigate chondrocyte apoptosis and ECM degradation by regulating the …
A clinical study found the concentration of mangiferin in plasma reached 38.64 ± 6.75 ng/ml …

… Runx2b, the key transcriptional gene in osteoblast differentiation, was downregulated in the
… -induced osteoclast formation (Ang, 2011). Our study confirmed that when mangiferin was …

… of Osterix + osteoprogenitors, and these endothelial cells could release osteogenic factors,
such as BMP2, to promote osteoblast differentiation and mineralization. Conversely, mature …

… Wnt antagonist and stimulates osteoblast differentiation. Hsu and Kuo (20) reported that DIO
has the ability to promote the differentiation and maturation of osteoblasts. These results are …

Developing novel strategies for defeating osteoporosis has become a world-wide challenge
with the aging of the population. In this work, novel supramolecular nanoagonists (NAs), …

… The findings indicate that Dexamethasone can impede osteoblasts by suppressing the
PI3K/Akt pathway within osteoblasts, leading to osteoblast damage. Dexamethasone, a synthetic …