The functional requirement for CD69 in establishment of resident memory CD8+ T cells varies with tissue location

DA Walsh, H Borges da Silva, LK Beura… - The Journal of …, 2019 - journals.aai.org
Using multiple mouse models of acute immunization, we found … on CD8 + T cell residency,
we explored generation of T RM … , we purified CD8 + T cells from the spleens of infected host …

Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage

JB Johnnidis, Y Muroyama, SF Ngiow, Z Chen… - Science …, 2021 - science.org
Generation of memory T cells is an essential part of protective immunity against pathogens
after initial infection … improve CD8 + T cell memory after vaccination through manipulating the …

[HTML][HTML] Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs

FM Behr, NAM Kragten, TH Wesselink, B Nota… - Frontiers in …, 2019 - frontiersin.org
… influenza infection using mice deficient for these transcription … the effector CD8 + T cell
response, and impairs the generation of … level, we could show that lung CD8 + T RM cells express …

[HTML][HTML] Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity

N Dumauthioz, B Tschumi, M Wenes, B Marti… - Cellular & molecular …, 2021 - nature.com
… the Trm generation, another long-lasting memory population. … time points after primary
infection, memory CD8 T cells were … of CD8 T cells, OCR (in pmol/min) was measured using the …

KLRG1+ memory CD8 T cells combine properties of short-lived effectors and long-lived memory

KR Renkema, MA Huggins… - The Journal of …, 2020 - journals.aai.org
infection determine the relative generation of these subsets and hence the generation of
durable CD8 T cell memory (… Using iv injection of Abs to label CD8 T cells in the vasculature and …

[HTML][HTML] SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells

AA Minervina, MV Pogorelyy, AM Kirk, JC Crawford… - Nature …, 2022 - nature.com
… that breakthrough infections diversify the T cell memory … by sequencing (CITE-seq) using the
10x Chromium platform. We observed … The generation of monoclonal T cell lines specific for …

[HTML][HTML] PD-1 dynamically regulates inflammation and development of brain-resident memory CD8 T cells during persistent viral encephalitis

Shwetank, EL Frost, TE Mockus, HM Ren… - Frontiers in …, 2019 - frontiersin.org
… persistent infection, if PD-1 operates to dampen CD8 T cellUsing adoptively transferred
transgenic CD8 T cells … that PD-1 might influence the generation of these cells. At 8 dpi, there …

T cell immunity to cytomegalovirus infection

N Zangger, A Oxenius - Current Opinion in Immunology, 2022 - Elsevier
… Interestingly, the generation of these cells depends on local … infection, a marked expansion
of innate-memory CD8 T cells (… Using mice deficient for MHC class 1a molecules, this study …

Bacterial Superantigens Expand and Activate, Rather than Delete or Incapacitate, Preexisting Antigen-Specific Memory CD8+ T Cells

CE Meilleur, CM Wardell, TS Mele… - … Journal of Infectious …, 2019 - academic.oup.com
… We also confirmed our findings using an in vivo … cytotoxicity was calculated as follows:
percentage of specific lysis = [(ER – … Of note, our model simulates memory T cell generation as a …

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade

RR Jadhav, SJ Im, B Hu, M Hashimoto… - Proceedings of the …, 2019 - National Acad Sciences
… for the generation of this stem-like CD8 T cell population … profiles of sorted CD8 T cell subsets
were examined using ATAC-seq … CD8 T cell subsets with effector and memory CD8 T cells