Kdm6b regulates the generation of effector CD8+ T cells by inducing chromatin accessibility in effector-associated genes

T Xu, A Schutte, L Jimenez, ANA Gonçalves… - The Journal of …, 2021 - journals.aai.org
… in the percentage and numbers of both mature CD4 and CD8memory CD8 + T cell
differentiation upon an acute infection, … Similar to our results using Kdm6b T cell–specific KO mice, …

TOX is expressed by exhausted and polyfunctional human effector memory CD8+ T cells

…, C Brander, P Nowak, PA Goepfert, DA Price… - Science …, 2020 - science.org
Using tetramers to examine the specificity of antigen-specific … To understand how an ongoing
systemic infection affects the … the acute memory phenotype described in mice infected with …

[PDF][PDF] Central memory CD8+ T cells derive from stem-like Tcf7hi effector cells in the absence of cytotoxic differentiation

DP Ferreira, JG Silva, T Wyss, SAF Marraco… - Immunity, 2020 - cell.com
CD8+ T cells that respond to infection and that have central … epigenetic landscape of CD8+
T cell subpopulations using ATAC-… in the generation and/or the function of d8 Tcf7GFPhi cells, …

[PDF][PDF] B cells promote CD8 T cell primary and memory responses to subunit vaccines

J Klarquist, EW Cross, SB Thompson, B Willett… - Cell reports, 2021 - cell.com
cells in the generation of CD8 T cell responses, we found that B … it had no impact on the
persistence of memory CD8 T cells. This … Using an in vivo killing assay, we found that CD8 T cell

Control of memory CD8+ T cell longevity and effector functions by IL-15

JC Nolz, MJ Richer - Molecular immunology, 2020 - Elsevier
… the memory CD8 + T cell response against re-infections. … In addition, the generation of soluble
IL-15/IL-15Rα complexes have … at manipulating the function of memory CD8 + T cells will …

[HTML][HTML] … electroporation augments checkpoint immunotherapy in prostate cancer and promotes tumor antigen-specific tissue-resident memory CD8+ T cells

BJ Burbach, SD O'Flanagan, Q Shao, KM Young… - Nature …, 2021 - nature.com
Using a transplantable mouse model of prostate carcinoma, … technique originally used
in infection settings 56 . SPAS-1+ … -C2 prostate carcinoma cell model, as the rate of tumor …

Replicative history marks transcriptional and functional disparity in the CD8+ T cell memory pool

K Bresser, L Kok, AC Swain, LA King, L Jacobs… - Nature …, 2022 - nature.com
… a–c, Kinetics of DR + OT-I T cells (a) and the percentage of … were superior in generating
offspring upon renewed infectionUsing the DivisionRecorder, we demonstrate that, as a whole…

[HTML][HTML] Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity

I Kavazović, H Han, G Balzaretti, E Slinger… - PLoS …, 2020 - journals.plos.org
… clonal diversity of the memory CD8 T-cell pool by mediating the … and Bcl-2 early after
CD8 T-cell activation, using a model in which … a 1:1 ratio and further processed for next-generation

Influenza, but not SARS‐CoV‐2, infection induces a rapid interferon response that wanes with age and diminished tissue‐resident memory CD8+ T cells

THO Nguyen, JL McAuley, Y Kim… - Clinical & …, 2021 - Wiley Online Library
… response following infection with influenza virus and severe acute … A, and the percentage
of different immune cells generating … -specific memory CD8 + T cells in lung of donors using a …

Peripherally induced brain tissue–resident memory CD8+ T cells mediate protection against CNS infection

SL Urban, IJ Jensen, Q Shan, LL Pewe, HH Xue… - Nature …, 2020 - nature.com
… , we compared CNS T RM cell generation in mice infected in with … The percentage of IV –
antigen-specific cells in the upper … TCR-tg T cell populations were gated using FlowJo software …