Insights into human genetic variation and population history from 929 diverse genomes

A Bergström, SA McCarthy, R Hui, MA Almarri, Q Ayub… - Science, 2020 - science.org
… 2A)], pointing to the importance of East Asia for understanding the early dispersal of non-…
of human genetic differentiation We next studied the extremes of human genetic variation by …

Genomic insights into the formation of human populations in East Asia

CC Wang, HY Yeh, AN Popov, HQ Zhang… - Nature, 2021 - nature.com
… Our current understanding of the human population history in the region remains poor because
of the minimal sampling of genetic diversity of present-day people on the Tibetan Plateau …

[PDF][PDF] Extensive ethnolinguistic diversity in Vietnam reflects multiple sources of genetic diversity

D Liu, NT Duong, ND Ton, N Van Phong… - Molecular biology …, 2020 - academic.oup.com
… and occupies a key position in Mainland Southeast Asia. Yet, the … genetic diversity, we find
that Vietnamese ethnolinguistic groups harbor multiple sources of genetic diversity that likely …

The GenomeAsia 100K Project enables genetic discoveries across Asia

Nature, 2019 - nature.com
… with 596 publicly available human genome sequences from … the broadest wealth of genetic
diversity; the dataset includes 598 … and comparative analysis of human genetic variation, we …

The formation of human populations in South and Central Asia

VM Narasimhan, N Patterson, P Moorjani, N Rohland… - Science, 2019 - science.org
… groups—the ANI and ASI—drive the main gradient of genetic variation in South Asia today.
genome-wide data from 523 individuals from Central Asia and northernmost South Asia from …

Human population history at the crossroads of East and Southeast Asia since 11,000 years ago

T Wang, W Wang, G Xie, Z Li, X Fan, Q Yang, X Wu… - Cell, 2021 - cell.com
… Past human genetic diversity and migration between southern China and Southeast Asia
the oldest humans sequenced from southern China. We discovered a deeply diverged East …

A first update on mapping the human genetic architecture of COVID-19

, … analyses team members: PC projection, gene … - Nature, 2022 - nature.com
… common in south Asian populations (minor allele frequency (MAF) = 0.027) than in European
populations (MAF = 0.0024), demonstrating the importance of diversity for variant discovery…

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Y Luo, M Kanai, W Choi, X Li, S Sakaue, K Yamamoto… - … genetics, 2021 - nature.com
… used to impute genetic variation at eight HLA classical genes accurately across a wide
range of populations. Accurate imputation in multi-ancestry studies is essential for fine-mapping. …

[HTML][HTML] Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

D Wu, J Dou, X Chai, C Bellis, A Wilm, CC Shih… - Cell, 2019 - cell.com
… great representation of Asian genetic diversity by three … diverse Asian and Oceanian
populations. These results highlight the value of our data as a resource to empower human genetics

African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
… in high genetic diversity and considerable population structure. Selected genetic variants …
are largely based on data from European and Asian-ancestry populations, which limits the …