Calcium promotes vascular smooth muscle cell phenotypic switching in Marfan syndrome

Y Yang, E Xie, Y Liu, Z Peng, C Yu, K Hua… - … and Biophysical Research …, 2023 - Elsevier
… Syyong et al. found that the frequency of calcium waves is reduced in the second-order
branches of the mesenteric artery of MFS mice (Fbn1 C1039G/+ ) at 24 weeks of age [26]. A …

Vascular Smooth Muscle Cell Mechanobiology in Aortopathies

RJ Wiener - 2023 - search.proquest.com
… the aorta, specifically Marfan syndrome, we studied whether … to increased stiffness, and
impaired vasodilation. In aging, changes … and Vasoconstriction in Murine Mesenteric Resistance

[HTML][HTML] Activation of Cav1. 2 and BKCa is involved in the downregulation of caffeine-induced contraction in mice mesenteric arteries

DCG Garcia, MJ Lopes, UC Mbiakop, VS Lemos… - Life sciences, 2019 - Elsevier
… 1.2 increased the TC while reduced the i Ca 2+ signal. Similar … of VSMCs contraction in
resistance arteries. The evidence of … when we compare Ca 2+ -sparks or Ca 2+ -waves [12]. In …

Aortic stiffness in L-NAME treated C57Bl/6 mice displays a shift from early endothelial dysfunction to late-term vascular smooth muscle cell dysfunction

S De Moudt, JO Hendrickx, C Neutel… - Frontiers in …, 2022 - frontiersin.org
… control mice, indicating that L-NAME treatment increases the … In this context, insulin-induced
vasodilation may represent a … and resistance arteries in L-NAME induced cardiovascular …

Intrinsic Mechanics of Human Stem Cell Derived Aortic Smooth Muscle Cells Support a Developmental Basis for Aneurysm Localization in Marfan Syndrome

RJ Wiener, H Orins, KD Costa - bioRxiv, 2023 - biorxiv.org
Marfan Syndrome Decreases Ca2+ Wave Frequency and Vasoconstriction in Murine Mesenteric
Resistance Arteries without Changing Underlying Mechanisms. JVR 48, 150–162 (2011…

The onset of cardiovascular disease in mice: an image-based, computational-experimental approach

L Aslanidou - 2019 - infoscience.epfl.ch
… Rp is peripheral resistance (summed resistance of peripheral beds)… As we saw, in Marfan
syndrome the defective synthesis of … rat mesenteric arteries to measure their vasoconstriction or …

Vascular smooth muscle cell PIEZO-1 in Abdominal Aortic Aneurysm formation

MA Waduud - 2023 - etheses.whiterose.ac.uk
… this work I had never handled a mouse or any animal, for that … through vasoconstriction
and vasodilation determined by … physiological decreases in peripheral resistance that occurs …

Central artery stiffness and thoracic aortopathy

JD Humphrey, G Tellides - American Journal of Physiology …, 2019 - journals.physiology.org
… We consider Marfan syndrome as an illustrative aortopathy … E57K/E57K mice but no effect
on muscular (renal, mesenteric, or … vasoconstriction can reduce wall stress overall (by reducing

Study of molecular causes underlying Williams-Beuren syndrome phenotype through the development of novel therapeutic approaches

P Ortiz Romero - 2019 - tdx.cat
… We have used a WBS mouse model carrying a heterozygous … of Ca2+ from intracellular
stores and the entry of Ca2+ from … triggering the response to vasoconstrictor signals by virtue of …

Investigating the Impact of Endothelial Dysfunction and Aging on Vascular Remodeling Using Mouse Models

L Du - 2022 - search.proquest.com
mesenteric arteries, located distally from the heart, which primarily constitute the vascular
resistance … resulting from tonic sympathetic neural input and vasoconstrictors, and vasodilation