[HTML][HTML] Mass spectrometry identification of biomarkers in extracellular vesicles from Plasmodium vivax liver hypnozoite infections
Latent liver stages termed hypnozoites cause relapsing Plasmodium vivax malaria infection
and represent a major obstacle in the goal of malaria elimination. Hypnozoites are clinically
undetectable, and presently, there are no biomarkers of this persistent parasite reservoir in
the human liver. Here, we have identified parasite and human proteins associated with
extracellular vesicles (EVs) secreted from in vivo infections exclusively containing
hypnozoites. We used P. vivax-infected human liver-chimeric (huHEP) FRG KO mice treated …
and represent a major obstacle in the goal of malaria elimination. Hypnozoites are clinically
undetectable, and presently, there are no biomarkers of this persistent parasite reservoir in
the human liver. Here, we have identified parasite and human proteins associated with
extracellular vesicles (EVs) secreted from in vivo infections exclusively containing
hypnozoites. We used P. vivax-infected human liver-chimeric (huHEP) FRG KO mice treated …
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