Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor

S Gao, K Liu, W Ku, D Wang, H Wake, H Qiao… - Frontiers in …, 2022 - frontiersin.org
… in vivo by a liberator of histamine from mast cells may be mediated in part by HMGB1.
These … injection of compound 48/80, a mast cell stimulator, in rats. The compound 48/80-induced

[HTML][HTML] Immune mechanisms in vulvodynia: key roles for mast cells and fibroblasts

E Tonc, GK Omwanda, KA Tovar… - Frontiers in Cellular …, 2023 - frontiersin.org
… labial skin of previously sensitized mice resulted in mast cell accumulation and remarkably
… of how immune mechanisms mediated by mast cells, fibroblasts and other cells contribute to …

Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation

S Antwi, D Oduro-Mensah, DD Obiri, N Osafo… - … Medicine and Therapies, 2022 - Springer
… Effect of Holarrhena floribunda stem bark extract on compound 48/80-induced systemic …
mediators released after mast cell degranulation. LPS-induced anaphylaxis is mediated in its …

(-)-Asarinin inhibits mast cells activation as a Src family kinase inhibitor

Y Hou, T Hu, D Wei, J Gao, D Che, X Wang… - … of Biochemistry & Cell …, 2020 - Elsevier
… local and system anaphylaxis of mice in vivo. Further … mast cell line LAD2 cells were used
as a model to detect the effect of Asa on IgE-mediate calcium mobilization and degranulation. …

[HTML][HTML] Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi

E Bencosme-Cuevas, TK Kim, TT Nguyen… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
… /c mice paw edema but did not significantly alter the mast cell … (A) Twelve retired female
BALB/c mice, divided into four … with saline, compound 48/80 (1 µg of mast cell degranulator), …

Immune actions on the peripheral nervous system in pain

JA Liu, J Yu, CW Cheung - International journal of molecular sciences, 2021 - mdpi.com
compound 48/80 induced degranulation of mast cells and caused … -mediated vasodilation
and mast cell degranulation were found to be key mechanisms in driving migraine in a mouse

Tetrahydrocannabinol reduces hapten-driven mast cell accumulation and persistent tactile sensitivity in mouse model of allergen-provoked localized vulvodynia

B Boo, R Kamath, E Arriaga-Gomez, J Landry… - International journal of …, 2019 - mdpi.com
… rather than degranulation. We have, in fact, previously shown that local, transient removal
of accumulated mast cells via secretagogue c48/80-mediated degranulation is associated with …

Natural α,β-unsaturated lactones inhibit neuropeptide-induced mast cell activation in an in vitro model of neurogenic inflammation

RC Coll, PM Vargas, ML Mariani, AB Penissi - Inflammation Research, 2020 - Springer
… substance P on mast cells are mediated either through the neurokinin-1 receptor (NK-1R)
or Mas-related G protein-coupled receptor (MRGPRX2 in humans; Mrgprb2 in mice and rats) [6…

Mast cells in inflammation and disease: recent progress and ongoing concerns

SJ Galli, N Gaudenzio, M Tsai - Annual review of immunology, 2020 - annualreviews.org
… induced different patterns of mouse mast cell degranulation that were … They found that
Mrgprb2-mediated mast cell activation … Thus, while FcεRI-mediated activation was associated with …

[HTML][HTML] … of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell …

AB Edwards, FL Mastaglia, NW Knuckey, KH Yip… - … and Biophysics Reports, 2022 - Elsevier
… the capacity of R18 and R18D to induce mast cell degranulation, as well as RBC hemolysis,
which … , as well as the potential of the peptides to cause anaphylactoid mediated reactions in …