The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
… the pathogenesis of PD, contributing to the loss of dopaminergic neurons [171]. Regarding
the therapeutic … factor and potential marker for monitoring the effects of treatment [203]. A …

Matrix metaloproteinases in vascular pathology

G Simões, T Pereira, A Caseiro - Microvascular Research, 2022 - Elsevier
… of the ECM by matrix metalloproteinases (MMPs) generates a … potential, and monitoring
the disease. New selective MMP … and elastin degradation, contributing to vascular stiffness; …

[HTML][HTML] Matrix metalloproteinases in renal diseases: a critical appraisal

O Zakiyanov, M Kalousová, T Zima… - Kidney and Blood Pressure …, 2019 - karger.com
… vascular smooth muscle cell proliferation and contributes to hypertrophic remodeling in the
aorta. … represent feasible marker candidates for diagnosis and surveillance in the follow-up of …

Matrilysins and stromelysins in pathogenesis and diagnostics of cancers

BM Piskór, A Przylipiak, E Dąbrowska… - Cancer management …, 2020 - Taylor & Francis
Matrix metalloproteinases (MMPs) are a family of secreted and … contributed to NSCLC cells
invasion and migration in vitro. Thus, MMP-26 may be served as a tumor marker in monitoring

Multifaceted role of matrix metalloproteinases in neurodegenerative diseases: Pathophysiological and therapeutic perspectives

T Behl, G Kaur, A Sehgal, S Bhardwaj, S Singh… - International Journal of …, 2021 - mdpi.com
… All authors have equal contribution to this paper and agreed to the final submitted manuscript.
Conceptualization, TB and GK; methodology, TB; investigation, SB (Shaveta Bhardwaj), …

Current perspectives on the role of matrix metalloproteinases in the pathogenesis of basal cell carcinoma

M Tampa, SR Georgescu, MI Mitran, CI Mitran, C Matei… - Biomolecules, 2021 - mdpi.com
… relies on the activity of membrane-type matrix metalloproteinases [27]. Using COS cells (ie, …
Moreover, MMPs modulate several signaling pathways that contribute to tumor progression, …

Association of plasma matrix metalloproteinase and tissue inhibitors of matrix metalloproteinase levels with adverse treatment outcomes among patients with …

NP Kumar, K Moideen, A Nancy… - JAMA Network …, 2020 - jamanetwork.com
… been postulated to play a key role in the pathogenesis of PTB. Matrix metalloproteinases
have been implicated in the pathology of lung tissue damage and cavitation because they have …

Matrix metalloproteinases as potential biomarkers and therapeutic targets in liver diseases

E Geervliet, R Bansal - Cells, 2020 - mdpi.com
… , monitoring and disease management. Notably, … pathophysiology and with considerable
data available from clinical trials on cancer, new approaches targeting MMPs could contribute

The role of matrix metalloproteinases (MMP-8, MMP-9, MMP-13) in periodontal and peri-implant pathological processes

I Luchian, A Goriuc, D Sandu, M Covasa - International Journal of …, 2022 - mdpi.com
pathogenesis of peri-implantitis, given its increase in fibroblasts from peri-implantitis [94] and
reduced gene expression of tissue inhibitors of matrix metalloproteinases (… thus contributing

Structure and function of human matrix metalloproteinases

H Laronha, J Caldeira - Cells, 2020 - mdpi.com
… MMPs have been recently recognized as biomarkers in several fields (diagnosis, monitoring,
and treatment efficacy) [19], … The S 3 pocket may also contribute to substrate specificity [1]. …