Development of a Radiopharmaceutical Carrier for PET Lung Perfusion Studies

S Shabnam - 2020 - theses.hal.science
… with gallium-68 eluate (68GaCl3). The presented radiopharmaceutical visualized the lungs
… generator for daily production of 68Ga and dose calibrator for dose measurements located …

Gallium-68 labelled radiopharmaceuticals for imaging inflammatory disorders

M Vorster - Seminars in Nuclear Medicine, 2023 - Elsevier
Gallium-68-based PET offers imaging possibilities for nearly … such as increases in vascular
permeability, changes in the … provides a measure of ROS activity in acutely injured lungs and …

Radiopharmaceutical labelling for lung ventilation/perfusion PET/CT imaging: a review of production and optimization processes for clinical use

F Blanc-Béguin, S Hennebicq, P Robin, R Tripier… - Pharmaceuticals, 2022 - mdpi.com
… However, carrier molecules are labelled with gallium-68 ( 68 Ga) … A total of 98% of activity
was measured in the lungs … binding affinity to the blood serum protein transferrin (log K1 = 20.3)…

Gallium Imaging of Infection and Inflammation

M Vorster, M Sathekge - Nuclear Medicine and Immunology, 2022 - Springer
transferrin, ferritin, and lactoferrin [7]. It stands to reason that … Vascular permeability increases
significantly to allow a … gallium imaging, especially gallium-68, as applied to PET imaging of …

Physiological Animal Imaging with 68Ga-Citrate

A Uğur, A Gültekin - Current radiopharmaceuticals, 2021 - ingentaconnect.com
… : Gallium-68 is an ideal research and hospital-based PET … , increased vascular permeability,
plasma transferrin binding and … 68Ga-citrate activity was measured in a Comecer VDC-606 …

Gallium: New developments and applications in radiopharmaceutics

PJ Blower, R Cusnir, A Darwesh, NJ Long… - Advances in Inorganic …, 2021 - Elsevier
… It is able to rapidly transchelate gallium bound to transferrin in … and gallium-68 (93%, 15 min,
RT, pH 4.5, [L] = 1 × 10 −4 M). … was designed as a gallium-68 labeled PET-PDT theranostic …

Nuclear Imaging of Inflammation

G Keeling, F Man - Imaging Inflammation, 2023 - Springer
… such as changes in vascular permeability, or much more targeted … A popular radiometal for
PET imaging is gallium-68. … with metal-binding proteins such as transferrin or ferritin, whereas …

Research Progress of [68Ga]Citrate PET's Utility in Infection and Inflammation Imaging: a Review

T Xu, Y Chen - Molecular Imaging and Biology, 2020 - Springer
… cause some problems for PET scanning. In the future, larger sample size studies will be …
in inflammatory sites through increased capillary permeability and transferrin binding. As there …

The radiopharmaceutical chemistry of the radionuclides of gallium and indium

JE Blower, MS Cooper, C Imberti, MT Ma… - Radiopharmaceutical …, 2019 - Springer
… is too short to match the long circulation time of transferrin. … developments that have led to
the advent of gallium-68 PET. … to be happy with the measures that the generator producers …

[HTML][HTML] [68Ga] Ga-4HMSA a promising new PET tracer for imaging inflammation

SK Ali, S Ait-Mohand, V Dumulon-Perreault… - EJNMMI …, 2021 - ncbi.nlm.nih.gov
… with DTPA, apo-transferrin and protein binding studies were … The radioactivity in each
fraction was measured using a dose … Gallium-68 PET: a powerful generator-based alternative to …