Manganese Porphyrins as Pro-Oxidants in High-Molar-Mass Hyaluronan Oxidative Degradation

K Valachová, P Rapta, I Batinic-Haberle… - Green Chemistry and …, 2020 - taylorfrancis.com
… antioxidative or pro-oxidative effects of Mn(II) ions and Mn-porphyrins such as Mn(III)…
Mechanism of the antitumor and radiosensitizing effects of a manganese porphyrin, MnHex-2-PyP

Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo

M Thamilarasan, R Estupinan… - Blood …, 2020 - ashpublications.org
… redox-active manganese (Mn) porphyrins MnTnBuOE-2-… mechanisms by Mn porphyrins
would result in decreased ROS levels. Although the preferred mode of action of Mn porphyrins

[HTML][HTML] Disrupting the vicious cycle created by NOX activation in sickle erythrocytes exposed to hypoxia/reoxygenation prevents adhesion and vasoocclusion

A MacKinney, E Woska, I Spasojevic, I Batinic-Haberle… - Redox biology, 2019 - Elsevier
… stress on the molecular mechanisms in SSRBCs involved in … redox-active manganese (Mn)
porphyrins, commonly known … the effect of H/R on ECs and the mechanism involved. H/R …

Superoxide Dismutase Mimetic Avasopasem Manganese Enhances Radiation Therapy Effectiveness in Soft Tissue Sarcomas and Accelerates Wound Healing

A Zaher, KA Mapuskar, MS Petronek, MR Tanas… - Antioxidants, 2024 - mdpi.com
… DNA damage is a primary mechanism of the action of RT [13]. H 2 O 2 -generating … a potent
radiosensitizer for STS cells and a radioprotective agent for NDFs, and this selective effect is …

Downregulation of Mcl-1 by panobinostat potentiates proton beam therapy in hepatocellular carcinoma cells

C Choi, GH Lee, A Son, GS Yoo, JI Yu, HC Park - Cells, 2021 - mdpi.com
radiosensitization by panobinostat (also called LBH589) in HCC cells. The radiosensitizing
… Autophagy-related cell death is another panobinostat’s anti-cancer mechanisms in HCC …

The novel SOD mimetic GC4419 increases cancer cell killing with sensitization to ionizing radiation while protecting normal cells

MA El-Mahdy, YA Alzarie, C Hemann… - Free Radical Biology …, 2020 - Elsevier
porphyrin-based mimetics are effective in decreasing IR-induced damage in normal tissue
and radio-sensitizing … enhanced the anti-cancer activity of IR with protection of normal cells. …

[PDF][PDF] Downregulation of Mcl-1 by Panobinostat Potentiates Proton Beam Therapy in Hepatocellular Carcinoma Cells. Cells 2021, 10, 554

C Choi, GH Lee, A Son, GS Yoo, JI Yu, HC Park - 2021 - researchgate.net
radiosensitization by panobinostat (also called LBH589) in HCC cells. The radiosensitizing
… Autophagy-related cell death is another panobinostat’s anti-cancer mechanisms in HCC …

Checkpoint kinase 1 (CHK1) inhibition enhances the sensitivity of triple-negative breast cancer cells to proton irradiation via Rad51 downregulation

C Choi, WK Cho, S Park, SW Shin, W Park… - International journal of …, 2020 - mdpi.com
radiosensitization by PF-477736 may be off-target effects, we … Radiosensitization in response
to CHK1 knockdown was … Impairment of HRR is one of the mechanisms by which CHK1 …

Different Antioxidant Efficacy of Two MnII-Containing Superoxide Anion Scavengers on Hypoxia/Reoxygenation-Exposed Cardiac Muscle Cells

M Becatti, A Bencini, S Nistri, L Conti, MG Fabbrini… - Scientific Reports, 2019 - nature.com
… as a parallel mechanism of action of Mn-porphyrins, adjunctive … -porphyrins have been shown
to exhibit protective effects by … Whether MnQ2 and MnM2, similarly to Mn-porphyrins, may …

A Review on the Recent Advancements on Therapeutic Effects of Metallic Ions in the Physiological Environments

M Awais, A Aziz, A Nazneen, A Wadood, MAU Rehman - 2022 - preprints.org
Anticancer effects of Gallium Ga complexes have been used … of immune system-based
mechanisms involving the role of … The mechanism of Ge-132’s anti-tumor activity includes the …