… antibodies recognize phospholipids and phospholipid-binding proteins and are not only …
conspirators including activated endothelial cells, platelets, and myeloid-lineage cells, as well …

… antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy morbidity in
the presence of antiphospholipid … C3a and C5a also activate endothelial cells, inducing the …

… mechanisms. These include a differentiation of pathogenic subtypes of antiphospholipid
antibodies (aPL), novel mechanisms … able to activate encrypted tissue factor on the cell surface …

… Binding of aPL to β2GPI on cellular surfaces activates endothelial cells, … activation, with the
net result leading to thrombosis and potential interference with trophoblast and decidual cells. …

… Activation of the complement cascade via antiphospholipid antibodies can cause … activation
from failure of these regulation mechanisms leads to complement‐mediated direct cellular …

… and phospholipid binding proteins at cell surfaces to activate the … T cells in shaping the
antiphospholipid syndrome antibody … B cell epitope relevant to antiphospholipid syndrome is in …

… The specific mechanisms connecting each neutrophil effector … erythematosus (SLE) and
antiphospholipid syndrome (APS) will … activation threshold and activation of autoreactive B-cells (…

… Tissue factor expressed by NETs also activates platelets, while cytokines released from
NETs participate in the activation of B cells and a new production of autoantibodies [18,21]. In …

Antiphospholipid syndrome (APS) is a multisystem autoimmune disease most commonly
associated with recurrent arterial and venous thromboembolism and recurrent fetal loss. Other …

… to the development of the antiphospholipid syndrome (APS). … findings on the origin and
mechanisms of production of APS-… , diminished endothelial cell activation, and adhesion …