… Cadet and co-workers investigated the mechanism for Iz formation via riboflavin photooxidation
… be formed by reaction of molecular oxygen with a transient intermediate radical, or as an …

… mechanism for the formation of 2Ih involving initial • OH addition to Gua at C5. This is
problematic for two … , it was found that one-electron oxidation reactions of nucleobases lead to a …

… a C4–C5 epoxide, which leads to 2Ih by an alternate mechanism. (47) … 3 to Grad is the
dominant step after C4 addition of OH radical. … found Sp and Iz as the dominant reaction products. …

… G encounters hydroxyl radicals, singlet oxygen, or one-electron … the mechanisms of 8-oxoG
+ deprotonation reaction, 15 … This may be due to the fact that the hydration models built in …

… hydroxyl radicals, superoxide, and hydrogen peroxide (H 2 O … quality control, and regulatory
mechanisms for redox-mediated … reaction, LSD1 generates local ROS (H 2 O 2 ) that lead to …

… Hydroxyl radicals (HO • ) are the most reactive species … reaction mechanism, involving the
production of HO • radical … , the DNA glycosylase which removes 8-oxoguanine in G:C pairs, a …

… Then, the detailed mechanisms of the formation of 8-oxoG and … reactions can lead to the
formation of 8-oxoG and Sp through multiple reaction pathways involving both OH radical and …

… living cells due to metabolic and biochemical reactions and due to … lead to oxidative DNA
damage. Within ROS-mediated DNA lesions, 8-oxoguanine (8-oxoG) and its nucleotide 8-oxo-2…

… ways that lead to DNA oxidation and the regulation of mechanisms … In addition, the mechanisms
of 8-oxo-dG formation and … OH radical through a homolytic reaction, releasing both • OH …

… two very different mechanisms, we show in Figure 2 the reaction of G with hydroxyl radical
vs… We show in Figure 2(A,B) that three mechanisms could lead to 8-hydroxyguanosine which …