Possible pathways of hepatotoxicity caused by chemical agents
R Mohi-Ud-Din, RH Mir, G Sawhney… - Current drug …, 2019 - ingentaconnect.com
… mechanisms of most drug-induced hepatotoxicity [6, 13, 14]. Even though the main mechanism
of DILI remains largely unknown, however, two pathways ie., direct hepatotoxicity and …
of DILI remains largely unknown, however, two pathways ie., direct hepatotoxicity and …
Integrative proteomics-metabolomics strategy reveals the mechanism of hepatotoxicity induced by Fructus Psoraleae
J Duan, W Dong, L Xie, S Fan, Y Xu, Y Li - Journal of proteomics, 2020 - Elsevier
… hepatotoxicity induced by aqueous extract of FP. In conclusion, integrative proteomics and
metabolomics provide the potential mechanism of hepatotoxicity … mechanism of hepatotoxicity …
metabolomics provide the potential mechanism of hepatotoxicity … mechanism of hepatotoxicity …
Acetaminophen hepatotoxicity
A Ramachandran, H Jaeschke - Seminars in liver disease, 2019 - thieme-connect.com
… These pathophysiological signaling mechanisms can be … Importantly, most of the mechanisms
have been confirmed in … newest insight into the intracellular mechanisms of APAP-induced …
have been confirmed in … newest insight into the intracellular mechanisms of APAP-induced …
[HTML][HTML] Pyrrolizidine alkaloids: An update on their metabolism and hepatotoxicity mechanism
J Xu, W Wang, X Yang, A Xiong, L Yang, Z Wang - Liver Research, 2019 - Elsevier
… the most hepatotoxic natural … mechanism is not fully understood. This review focuses on
updating the information on the metabolism and the molecular mechanisms of PAs hepatotoxicity…
updating the information on the metabolism and the molecular mechanisms of PAs hepatotoxicity…
[HTML][HTML] Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities
… on investigating the mechanisms of hepatotoxicity, with limited … APAP hepatotoxicity–induced
liver regeneration involves a … Despite recent efforts to study the mechanisms of liver …
liver regeneration involves a … Despite recent efforts to study the mechanisms of liver …
Central mechanisms of acetaminophen hepatotoxicity: Mitochondrial dysfunction by protein adducts and oxidant stress
H Jaeschke, A Ramachandran - Drug Metabolism and …, 2024 - dmd.aspetjournals.org
… understand the molecular mechanisms of liver … mechanisms, and this review gives an
overview of major findings resulting from studying the role of mitochondria in APAP hepatotoxicity …
overview of major findings resulting from studying the role of mitochondria in APAP hepatotoxicity …
Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium)-induced hepatotoxicity–A review
K Renu, R Chakraborty, H Myakala, R Koti… - Chemosphere, 2021 - Elsevier
Heavy metals pose a serious threat if they go beyond permissible limits in our bodies. Much
heavy metal’s viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious …
heavy metal’s viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious …
Mitochondria as the target of hepatotoxicity and drug-induced liver injury: molecular mechanisms and detection methods
M Mihajlovic, M Vinken - International journal of molecular sciences, 2022 - mdpi.com
… Hepatotoxicity linked to mitochondrial dysfunction can be … Next, we review the main
mechanisms of liver injury with a … DILI and mitochondria-related hepatotoxicity, as well as the most …
mechanisms of liver injury with a … DILI and mitochondria-related hepatotoxicity, as well as the most …
The DILI‐sim initiative: insights into hepatotoxicity mechanisms and biomarker interpretation
PB Watkins - Clinical and Translational Science, 2019 - Wiley Online Library
… The DILI-sim Initiative has advanced our understanding of mechanisms underlying DILI and
this has provided insight into species differences in susceptibility to hepatotoxicity as well as …
this has provided insight into species differences in susceptibility to hepatotoxicity as well as …
The development and hepatotoxicity of acetaminophen: reviewing over a century of progress
MR McGill, JA Hinson - Drug metabolism reviews, 2020 - Taylor & Francis
… than rats, and develop hepatotoxicity at doses that are quite … animal to investigate mechanisms
of APAP hepatotoxicity. In mice, … of the mechanisms of APAP-induced hepatotoxicity. …
of APAP hepatotoxicity. In mice, … of the mechanisms of APAP-induced hepatotoxicity. …