Cell death pathways in ischemic stroke and targeted pharmacotherapy

A Datta, D Sarmah, L Mounica, H Kaur… - Translational stroke …, 2020 - Springer
mechanisms involved in post-ischemic cell death. This review will be mainly focusing on the
critical cell death pathways which occur after ischemia … of autophagy is its dynamic nature. …

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
… the purely unregulated nature of necrosis was challenged, and necrotic cell death has since
… a well-regulated and orchestrated event like apoptosis. In contrast to apoptosis, necroptosis …

[HTML][HTML] Neuronal death mechanisms and therapeutic strategy in ischemic stroke

R Mao, N Zong, Y Hu, Y Chen, Y Xu - Neuroscience bulletin, 2022 - Springer
… intersect in promoting cell death. Here, we review the mechanisms of the significant events
… T and B lymphocyte-mediated adaptive immune response. The antigen in reactive astrocytes …

Regulatory T cells in ischemic stroke

H Wang, J Ye, L Cui, S Chu, N Chen - Acta Pharmacologica Sinica, 2022 - nature.com
… how Treg cells modulate the immune responses induced by … , and summarize their biological
functions and mechanisms in … of IL-10 derived from Treg cells and apoptotic cell death [93]. …

[HTML][HTML] Glial cells: role of the immune response in ischemic stroke

S Xu, J Lu, A Shao, JH Zhang, J Zhang - Frontiers in immunology, 2020 - frontiersin.org
… the mechanisms of post-stroke immune regulation mediated … Ischemia induces cell death
and cell dysfunction by … CD8+ T cells and nature killer cells and promotes their function, thereby …

[HTML][HTML] Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs

T Zhu, L Wang, L Wang, Q Wan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
ischemic stroke. We aimed to review the current understandings of the underlying mechanisms
of … This autophagic cell death is often accompanied by cell apoptosis and cell necrosis, …

[HTML][HTML] Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
… with ischemic stroke, specifically the role of immune factors. … that it causes rapid cell death.
However, at the periphery (… , natural IL-17–secreting γδ T cells contribute to ischemic injury by …

[HTML][HTML] Adaptive immunity regulation and cerebral ischemia

X Qin, F Akter, L Qin, J Cheng, M Guo, S Yao… - Frontiers in …, 2020 - frontiersin.org
… of the adaptive immune system in cerebral ischemia and … evidence of reduced neuronal cell
death following use of FasL … exploited this mechanism to induce immunological tolerance to …

[HTML][HTML] Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective

T Tao, M Liu, M Chen, Y Luo, C Wang, T Xu… - Pharmacology & …, 2020 - Elsevier
… leads to cell death. The proinflammatory signals secreted by … Most of them are natural
antioxidants that regulate oxidative … effects and mechanisms of natural medicines based on natural

[HTML][HTML] Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches

CD Maida, RL Norrito, M Daidone… - International journal of …, 2020 - mdpi.com
… of the immune system involved in ischemic stroke, focusing … after ischemia, leads to an
increased neuronal cell death … of influencing the nature of the cerebral ischemia and the extension …