Mechanisms of oocyte aneuploidy associated with advanced maternal age

M Mikwar, AJ MacFarlane, F Marchetti - Mutation Research/Reviews in …, 2020 - Elsevier
It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years
of age. In particular, chromosome segregation errors during meiotic divisions are
increasingly common and lead to the production of oocytes with an incorrect number of
chromosomes, a condition known as aneuploidy. When an aneuploid oocyte is fertilized by
a sperm it gives rise to an aneuploid embryo that, except in rare situations, will result in a …
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