Dynamic behavior of polymer microbubbles during long ultrasound tone-burst excitation and its application for sonoreperfusion therapy

X Chen, X Chen, J Wang, TH Francois… - Ultrasound in medicine …, 2023 - Elsevier
… of polymer-shelled MBs compared with lipid MBs, we investigated the dynamic behavior
of polymer microbubbles and their therapeutic potential for sonoreperfusion (SRP) therapy. …

[HTML][HTML] Opening of endothelial cell–cell contacts due to sonoporation

I Beekers, M Vegter, KR Lattwein, F Mastik… - Journal of Controlled …, 2020 - Elsevier
… a cellular response upon sonoporation and did not correlate with the microbubble excursion
… is a cellular response mechanism and not directly caused by a microbubble mechanically …

[HTML][HTML] Ultrasound-responsive cavitation nuclei for therapy and drug delivery

K Kooiman, S Roovers, SAG Langeveld… - Ultrasound in medicine …, 2020 - Elsevier
… investigated cavitation nuclei were gas microbubbles, ∼1–10 … This review focuses on the
latest insights into cavitation nuclei … The cationic microbubbles utilized in the treatment sections …

[HTML][HTML] Applications of ultrasound-mediated drug delivery and gene therapy

J Sitta, CM Howard - International Journal of Molecular Sciences, 2021 - mdpi.com
… A second mechanism used by the ultrasound microbubble … The biological effects of
microbubble sonoporation on the … stability and targeting by coating with polymers, proteins, or …

[HTML][HTML] Polymeric materials for ultrasound imaging and therapy

RA Barmin, MJ Moosavifar, A Dasgupta… - Chemical …, 2023 - pubs.rsc.org
… chemical toolbox to engineer polymer shell properties and … applications of polymeric
microbubbles in molecular imaging, … Hence, this study demonstrated that sonoporation efficiency …

Ultrasound-stimulated microbubble induced fluid transport in poroviscohyperelastic media

K Kiezun - 2022 - search.proquest.com
mechanism by which a microbubble situated at the boundary of a porous viscoelastic medium
may actively induce fluid transport into … a lipid, protein, or polymer shell in order to extend …

[HTML][HTML] Acoustically-stimulated nanobubbles: opportunities in medical ultrasound imaging and therapy

B Helfield, Y Zou, N Matsuura - Frontiers in Physics, 2021 - frontiersin.org
sonoporation [20, 21]. Through co-injection of a therapeutic or the attachment of therapeutic
cargo to the microbubble itself, ultrasound-triggered microbubbles … for ultrasound-stimulated

Transendothelial perforations and the sphere of influence of single-site sonoporation

B Helfield, X Chen, SC Watkins… - Ultrasound in medicine & …, 2020 - Elsevier
… opening) through the sonoporation mechanism differ by a … the addition of an actin monomer
(ie, polymerization; ∼10 7 /M/s) (… Ultrasound-stimulated microbubble-mediated intracellular …

Ultrasound molecular imaging-guided tumor gene therapy through dual-targeted cationic microbubbles

Y Liu, Y Zhou, J Xu, H Luo, Y Zhu, X Zeng… - Biomaterials …, 2021 - pubs.rsc.org
… cationic liposomes and cationic polymers have been shown … Under ultrasound (US) irradiation
conditions, microbubblessonoporation) by which genes or drugs can easily enter into the …

[HTML][HTML] Ultrasound and nanomedicine for cancer-targeted drug delivery: screening, cellular mechanisms and therapeutic opportunities

CH Li, YC Chang, M Hsiao, MH Chan - Pharmaceutics, 2022 - mdpi.com
… By filling the interior of lipospheres with gas molecules, these particles can serve both as
contrast agents for ultrasonic imaging and as delivery systems for drugs such as microbubbles