… trithorax (SET) domain, involved in methylation of lysine 4 at … certain Hox genes (associated
with a locus specific decrease in … In addition, genes bound by the histone methyltransferase …

… MLL and trithorax regulate the expression of a subset of … decreased Hoxc8 expression [31],
indicating that MENIN is a … of histone H3 lysine 4 (H3K4me1) at the Hoxc8 locus were …

… ) catalyse methylation of histone H3K4, which is associated … importance of the
polycomb–trithorax axis for normal cellular … of KMT2A, we identified loci that showed either …

… transformation associated with MEN1 requires complete loss of MENIN protein or … Menin
associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus…

… Menin associates with a trithorax family histone methyltransferase complex and with the
Hoxc8 locus. … a SET1-like histone methyltransferase complex with menin to regulate Hox gene …

… of menin inhibitors in breast cancer treatment remain limited. In this review, we focused on
the menin associated … fusion proteins with decreased H3K4me3 at the gene loci. Interaction of …

… also inhibit menin–MLL1, menin–MLL2, and other menin-interacting … of menin–MLL-FP
interactions or menin–MLL1/MLL2 interactions contribute to the antileukemia effect of menin …

… complex, a H3K4 methyltransferase, we reduced the proliferative capacity and H3K4me1-associated
loci in … MLL is a component of a SET-1-like histone methyl-transferase complex that …

… The Trithorax group of proteins has been identified as regulators of Homeotic (Homeobox) …
to recruit the complexes to specific gene loci. Among them, Menin has been demonstrated to …

… We found that genomic loci where NF-YA and Menin signals … increase in histone modifications
associated with gene … , including a JmjC histone demethylase domain that catalyzes the …