Introduction Cerebral small vessel disease (CSVD) causes a quarter of all strokes and is the
most common pathology underlying vascular dementia. However, the mechanism of CSVD
remains unclear. Numerous studies have investigated whether the angiotensin-converting
enzyme (ACE) intersection/deletion (I/D) polymorphism influences the risk of CSVD, but the
results are controversial. Methods We searched English and Chinese databases and
calculated the odds ratio (OR) and 95% confidence interval (CI) to examine the existence of …

Rec ent studies have suggested a closer association between angiotensin-converting
enzyme (ACE) gene polymorphisms and polycystic ovary syndrome (PCOS) risk, but the
results were inconsistent. We conducted this meta-analysis to explore the precise
associations between ACE gene I/D polymorphism and PCOS risk. Online electronic
databases (PubMed, Embase, SCI index, CNKI, and Wanfang) were searched. Odds ratios
(ORs) with 95% confidence interval (CIs) were calculated to assess the association between …