[HTML][HTML] Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway
Y Jia, R Cui, C Wang, Y Feng, Z Li, Y Tong, K Qu, C Liu… - Redox biology, 2020 - Elsevier
Intestinal ischemia-reperfusion (I/R) injury is a life-threatening vascular emergency and has
long been a disturbing problem for surgeons. Oxidative stress is considered a vital factor in
I/R injury. Metformin has anti-oxidative properties and protects against I/R injury. The present
study aimed to investigate whether Metformin protects against intestinal I/R injury and reveal
the protective mechanism of Metformin. I/R injury was induced in mice by temporary superior
mesenteric artery occlusion, and Caco-2 cells were subjected to OGD/R to establish an in …
long been a disturbing problem for surgeons. Oxidative stress is considered a vital factor in
I/R injury. Metformin has anti-oxidative properties and protects against I/R injury. The present
study aimed to investigate whether Metformin protects against intestinal I/R injury and reveal
the protective mechanism of Metformin. I/R injury was induced in mice by temporary superior
mesenteric artery occlusion, and Caco-2 cells were subjected to OGD/R to establish an in …
[HTML][HTML] Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway
J Zhang, L Huang, X Shi, L Yang, F Hua, J Ma… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Abstract Ischemia/reperfusion (I/R) injury is a life-threatening vascular emergency following
myocardial infarction. Our previous study showed cardioprotective effects of metformin
against myocardial I/R injury. In this study, we further examined the involvement of AMPK
mediated activation of NLRP3 inflammasome in this cardioprotective effect of metformin.
Myocardial I/R injury was simulated in a rat heart Langendorff model and neonatal rat
ventricle myocytes (NRVMs) were subjected to hypoxi/reoxygenation (H/R) to establish an in …
myocardial infarction. Our previous study showed cardioprotective effects of metformin
against myocardial I/R injury. In this study, we further examined the involvement of AMPK
mediated activation of NLRP3 inflammasome in this cardioprotective effect of metformin.
Myocardial I/R injury was simulated in a rat heart Langendorff model and neonatal rat
ventricle myocytes (NRVMs) were subjected to hypoxi/reoxygenation (H/R) to establish an in …
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