… RyR2 mutations cause SCD, we generated a knock-in mouse model … , we show that CRDS
RyR2-D4646A +/− LOF mutation … phenotype lacks catecholamine-induced ventricular ectopy, …

… sequence variants in the cardiac ryanodine receptor (RyR2) … R176Q mice increasing
gRNA specificity for the mutant allele… catecholamine-induced VT in RYR2 R4496C mice and …

… generated a mouse model that carried the A690E mutation. … by a combination of
catecholamine-induced VT underlying QT interval … Mutation R176Q caused cardiac dysfunction …

… We thus established a mouse pedigree harboring a novel ryanodine receptor 2 gene (Ryr2)
missense mutation that exhibited bidirectional ventricular tachycardia (BVT) spontaneously …

… RYR2 gene encoding the type 2 ryanodine receptor (RyR2)[7]. … induction of ventricular
tachycardia in 6 of 8 R176Q/+ mice that … -SaCas9-treated R176Q/+ mice exhibited a significantly …

… reported that cardiac ryanodine receptor mutations caused … WT mice, the Tecrl KO mice
cardiomyocytes exhibited similar … ) to neonatal mice with a known CPVT mutation (RyR2 R176Q/…

… polymorphic ventricular tachycardia (CPVT) is a cardiac channelopathy causing ventricular
… Pathogenic variants in RYR2-encoded ryanodine receptor 2 (RYR2) cause CPVT1 and …

… with a mutation in the human cardiac ryanodine receptor gene … [ 22 ] When such a population
of mice underwent a … [ 11 ] Human cardiac cells harboring the D307H mutation exhibit …

… , dominant mutations in the type 2 ryanodine receptor (RYR2) … protected CPVT mice from
catecholamine-induced ventricular … induced arrhythmias in Ryr2 R176Q/+ mice treated with the …

… We also show that the RyR2 N-terminus domain interacts … R176Q mutation linked with
arrhythmogenic right ventricular … 39 whereas ventricular myocytes from A4860G knockin mice had …