Gene expression changes induced by valproate in the process of rat hippocampal neural stem cells differentiation

H He, W Li, B Shen, H Zhao, J Liu, J Qin… - Cell Biology …, 2020 - Wiley Online Library
… , has been believed to induce neuronal differentiation at the … VPA/miRNA/mRNA axes during
neuronal differentiation. This … gene expression profiles of rat hippocampal NSCs following

MicroRNA alterations in induced pluripotent stem cell-derived neurons from bipolar disorder patients: pathways involved in neuronal differentiation, axon guidance …

M Bame, MG McInnis, KS O'Shea - Stem cells and development, 2020 - liebertpub.com
… In fact, valproate has been shown to degrade DICER, which … are required to maintain stemness
of neural stem cell [120,121]. … Altered microRNA expression profiles in postmortem brain …

MicroRNAs, stem cells in bipolar disorder, and lithium therapeutic approach

D Coradduzza, G Garroni, A Congiargiu… - International Journal of …, 2022 - mdpi.com
… influencing stem cells located in the niche [56] by inducing … treatment with lithium and
valproate, after treatment, miR-34a … and function, together with neural stem cells and their …

Downregulation of MicroRNA-34c-5p facilitated neuroinflammation in drug-resistant epilepsy

M Fu, J Tao, D Wang, Z Zhang, X Wang, Y Ji, Z Li - Brain Research, 2020 - Elsevier
… , but the mechanisms underlying the induction of epilepsy remain … A gene expression profile
dataset, GSE99455, was … groups and were given 250 mg/kg valproic acid (VPA, Sanofi, USA…

Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle

W Li, S Wang, H He, J Qin, X Cheng, H Zhao… - Stem Cell Research & …, 2021 - Springer
… neurogenesis in rats after fimbria fornix transection in vivo. … , as well as the induction of
lineage-specific transcription … and supplied in the miRcute miRNA qPCR Detection Kit. The 2 …

Therapeutic potential of mesenchymal stem cells in the treatment of epilepsy and their interaction with antiseizure medications

MR Tesiye, M Gol, MR Fadardi, SNM Kani, AM Costa… - Cells, 2022 - mdpi.com
… an increased duration of follow-up after epilepsy surgery [5]. … Various ASMs, such as sodium
valproate (VPA), are used as … the adverse effects of stem cells include the induction of some …

Drugs used to treat bipolar disorder act via microRNAs to regulate expression of genes involved in neurite outgrowth

S Kidnapillai, B Wade, CC Bortolasci… - Journal of …, 2020 - journals.sagepub.com
… , valproate, lamotrigine and quetiapine) in cultured human … Ntera-2 (NT2)-N cells following
treatment with the bipolar disorder (BD… include using miRNA expression profiles as molecular …

MicroRNAs and target genes in epileptogenesis

Y Feng, H Yang, Y Yue, F Tian - Epilepsia, 2020 - Wiley Online Library
… are found in the miRNA expression profile of kainic acid–… with the anticonvulsant drug valproic
acid, 87 demonstrating that miR… Thus, miR-128 is a powerful factor for inducing epilepsy in …

Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells

TW Kowalski, VO Lord, E Sgarioni… - European …, 2022 - Elsevier
expression, named transcriptome (Lauschke et al., 2020, 2021; Sotthibundhu et al., 2021).
Evaluation of the human cell's transcriptome after VPA … induce the clinical signs seen in FVSD. …

Neuronal activity promotes glioma progression by inducing proneural-to-mesenchymal transition in glioma stem cells

X Guo, W Qiu, C Wang, Y Qi, B Li, S Wang, R Zhao… - Cancer Research, 2024 - AACR
… GBM cell lines that are less stem-like (A172 and LN229) after … that neuronal activity promotes
GBM progression by inducing … Specifically, neuronal activity modifies the miRNA profiles of …