… [ 95 ] One prominent example of an EC mechanotransducer is … Biophysical modification
strategies include modulation of … into myofibroblasts, and deposition of collagen I over time …

… in vitro microenvironment biochemical and biophysical properties that can be tuned, and
their role in modulating CM … The cardiac fibrosis region is characterized by wall stiffening, 1 2 …

… of the heart, myofibroblasts produce an … vitro the strain these cells normally experience
in vivo to promote elongation and alignment. These cells will then be built into a 3D cardiac …

… tissue models which allow us to test control strategies in vitro… localization of the
mechanotransducer YAP, consisting in an … engineered through using ie micro-engineered …

… Yes-associated protein (YAP) as a mechanotransducer links … However, activated myofibroblasts
can decrease chromatin … activity through epigenetic splicing and accordingly modulates …

… , responsible for circulating blood throughout the body. Reliable in vitro models for the heart
are critical for research areas focused on understand- ing cardiac diseases and drug testing. …

… stiffening or softening on modulating cell behavior and fate … of hepatic stellate cells
from myofibroblast to fibroblast, … , 39 regarding as a core mechanotransducer. Thus, long-term …