Mitochondrial calcium signaling as a therapeutic target for Alzheimer's disease
… and neurodegenerative diseases such as Huntington's disease [79]. … , DS44170716,
minocycline and doxycycline, have been … neuroinflammation in AD animal models. However, …
minocycline and doxycycline, have been … neuroinflammation in AD animal models. However, …
[HTML][HTML] Advances in Neuropathic Pain Research: Selected Intracellular Factors as Potential Targets for Multidirectional Analgesics
K Ciapała, J Mika - Pharmaceuticals, 2023 - mdpi.com
… The latest data suggest that minocycline has beneficial effects on relieving diabetes-… ,
minocycline in a rat model of streptozotocin-induced diabetic neuropathy also has a beneficial …
minocycline in a rat model of streptozotocin-induced diabetic neuropathy also has a beneficial …
[HTML][HTML] Small heterodimer partner (SHP) aggravates ER stress in Parkinson's disease-linked LRRK2 mutant astrocyte by regulating XBP1 SUMOylation
JH Lee, J Han, E Joe, I Jou - Journal of Biomedical Science, 2021 - Springer
… milieu and type of neurodegenerative disorder. Here, we suggest that doxycycline may
selectively apply to the PD-related LRRK2-G2019S mutation model. Additional studies are …
selectively apply to the PD-related LRRK2-G2019S mutation model. Additional studies are …
Therapeutic implications of phosphorylation-and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration
… Prior to rotenone administration, minocycline treatment … Huntington's disease (HD) is a
severe autosomal dominant … Doxycycline resulted in a significant increase in activated BDNF …
severe autosomal dominant … Doxycycline resulted in a significant increase in activated BDNF …
[PDF][PDF] Oral minocycline challenge as a potential first line therapy for myalgic encephalomyelitis and long COVID-19 syndrome
K Miwa - Ann Clin Med Case Rep, 2022 - acmcasereport.org
… with doxycycline, … models of ischemia, traumatic brain injury, and neuropathic pain, as
well as several neurodegenerative conditions, such as Parkinson and Huntington diseases, …
well as several neurodegenerative conditions, such as Parkinson and Huntington diseases, …
Could Antibiotics Be Therapeutic Agents in Alzheimer's Disease?
O Gómez-Torres, C Pintado-Losa… - … -Alzheimer Disorders, 2019 - books.google.com
… In a Drosophila model of Aβ toxicity, doxycycline prevents Aβ … such huntingtin in Huntington
disease mice model [181]. … , we should not forget that a suitable minocycline doses must …
disease mice model [181]. … , we should not forget that a suitable minocycline doses must …
[HTML][HTML] Enhanced targeted delivery of minocycline via transferrin conjugated albumin nanoparticle improves neuroprotection in a blast traumatic brain injury model
… minocycline using targeted nanoparticles in a rat model of TBI. The results show maximal
concentration (~3′ fold higher) of minocycline … to the free minocycline injection group. This is …
concentration (~3′ fold higher) of minocycline … to the free minocycline injection group. This is …
Rescuing tetracycline class antibiotics for the treatment of multidrug-resistant Acinetobacter baumannii pulmonary infection
… In vitro, the combination of PBT2 and zinc with either tetracycline, doxycycline, or tigecycline
was shown to be bactericidal against multidrug-resistant A. baumannii , and any resistance …
was shown to be bactericidal against multidrug-resistant A. baumannii , and any resistance …
… Immune Responses Control Viral Growth and Protect against Neuronal Death in an Ex Vivo Model of West Nile Virus-Induced Central Nervous System Disease
P Clarke, JS Leser, KL Tyler - Journal of Virology, 2021 - Am Soc Microbiol
… protective in several models of CNS injury and disease (39… , we show that rosiglitazone
treatment was not protective in WNV-… Minocycline is a tetracycline antibiotic that can inhibit the …
treatment was not protective in WNV-… Minocycline is a tetracycline antibiotic that can inhibit the …
Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and …
… Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease (PD),
and Huntington disease (HD) represent a major socio-economic challenge in view of their …
and Huntington disease (HD) represent a major socio-economic challenge in view of their …