Minocycline attenuates microglia/macrophage phagocytic activity and inhibits SAH-induced neuronal cell death and inflammation
KG Blecharz-Lang, V Patsouris, M Nieminen-Kelhä… - Neurocritical Care, 2022 - Springer
… by minocycline administration after SAH. Moreover, the SAH-induced overexpression of
pro-inflammatory cytokines and neuronal cell death was markedly attenuated by the compound. …
pro-inflammatory cytokines and neuronal cell death was markedly attenuated by the compound. …
Bee venom alleviated edema and pain in monosodium urate crystals-induced gouty arthritis in rat by inhibiting inflammation
B Goo, J Lee, C Park, T Yune, Y Park - Toxins, 2021 - mdpi.com
… confirmed histologically to attenuate synovitis and neutrophil … To evaluate the effect of BV
in a gouty animal model, we … of blood cells, thereby facilitating inflammatory responses [14]. …
in a gouty animal model, we … of blood cells, thereby facilitating inflammatory responses [14]. …
Celastrol ameliorates inflammatory pain and modulates HMGB1/NF-κB signaling pathway in dorsal root ganglion
X Zhang, W Zhao, X Liu, Z Huang, R Shan, C Huang - Neuroscience letters, 2019 - Elsevier
… (CFA)-induced inflammatory pain rat model was used. Paw … of antibody to COX-2 attenuates
pain hypersensitivity [8]. In … , and the production of pro-inflammatory cytokines, inflammatory …
pain hypersensitivity [8]. In … , and the production of pro-inflammatory cytokines, inflammatory …
Role of microglia and P2X4 receptors in chronic pain
K Kohno, M Tsuda - Pain Reports, 2021 - journals.lww.com
… attenuated pain behavior and reduced expression of BDNF. … neurons, which caused facilitated
pain transmission. These … of minocycline does not improve pain resolution after surgery, …
pain transmission. These … of minocycline does not improve pain resolution after surgery, …
Chemogenetic regulation of CX3CR1-expressing microglia using Gi-DREADD exerts sex-dependent anti-allodynic effects in mouse models of neuropathic pain
F Saika, S Matsuzaki, D Kobayashi… - Frontiers in …, 2020 - frontiersin.org
… pain assessment was performed the day after each administration. PSL-induced mechanical
allodynia was significantly attenuated … inhibitors, such as minocycline and propentofylline. …
allodynia was significantly attenuated … inhibitors, such as minocycline and propentofylline. …
Chemogenetic and optogenetic manipulations of microglia in chronic pain
S Parusel, MH Yi, CL Hunt, LJ Wu - Neuroscience Bulletin, 2023 - Springer
… minocycline attenuates pain hypersensitivity [7, 8]. However, … for pro-inflammatory cytokine
production or release [58, 71]. … in CX3CR1 + cells attenuates mechanical allodynia after PSL …
production or release [58, 71]. … in CX3CR1 + cells attenuates mechanical allodynia after PSL …
Neuroimmune interactions in pain and stress: an interdisciplinary approach
CM Sawicki, ML Humeidan… - The neuroscientist, 2021 - journals.sagepub.com
… demonstrated that administration of minocycline, a known … interactions likely contribute to
descending pain facilitation. … neutralizing antibody attenuated mechanical allodynia in rats with …
descending pain facilitation. … neutralizing antibody attenuated mechanical allodynia in rats with …
… administration of a β2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post …
… mechanical hypersensitivity over a wide dose range spinal β2 AR stimulation may not be
sufficient to attenuate mechanical hypersensitivity in the current model. … anti-allodynic effects of …
sufficient to attenuate mechanical hypersensitivity in the current model. … anti-allodynic effects of …
Interferon-γ facilitates the synaptic transmission between primary afferent C-fibres and lamina I neurons in the rat spinal dorsal horn via microglia activation
G Reischer, B Heinke, J Sandkühler - Molecular Pain, 2020 - journals.sagepub.com
… In addition, mice lacking IFNγ receptors show attenuation of … we applied the microglial
inhibitor minocycline (100 µM) prior … Another main finding of this study was that the facilitation of …
inhibitor minocycline (100 µM) prior … Another main finding of this study was that the facilitation of …
IKBKB siRNA-Encapsulated Poly (Lactic-co-Glycolic Acid) Nanoparticles Diminish Neuropathic Pain by Inhibiting Microglial Activation
S Lee, HJ Shin, C Noh, SI Kim, YK Ko, SY Lee… - International Journal of …, 2021 - mdpi.com
… Methods of directly targeting microglial cells, such as minocycline, have been tried, but …
PLGA nanoparticles attenuated the expression of proinflammatory mediators in SNL rat models. (…
PLGA nanoparticles attenuated the expression of proinflammatory mediators in SNL rat models. (…