Prevention and treatment for chemotherapy-induced peripheral neuropathy: therapies based on CIPN mechanisms

LY Hu, WL Mi, GC Wu, YQ Wang… - Current …, 2019 - ingentaconnect.com
… resulted in attenuated mechanical allodynia in CIPN animal models [23, 30, 31]. … Mahony,
JH; Maier, SF; Watkins, LR Minocycline attenuates mechanical allodynia and … facilitation. …

p38 mitogen-activated protein kinase and pain

L Mai, X Zhu, F Huang, H He, W Fan - Life sciences, 2020 - Elsevier
… play an important role in pain facilitation. The activation of … its receptor TrkA mediating
mechanical allodynia [120,121]. In … important role in pain regulation in different animal models, in …

Angiotensin II type 2 receptor pharmacological agonist, C21, reduces the inflammation and pain hypersensitivity in mice with joint inflammatory pain

W Gao, L Shen, D Long, T Pan, D Wang, X Chai… - International …, 2022 - Elsevier
… of AT 2 R gene facilitated both of pain hypersensitivity and knee … showed that intrathecal
minocycline inhibited classical … attenuated hind paw hypersensitivity, both mechanical and …

Dimethyl Itaconate Attenuates CFA-Induced Inflammatory Pain via the NLRP3/ IL-1β Signaling Pathway

J Lin, J Ren, B Zhu, Y Dai, DS Gao, S Xia… - Frontiers in …, 2022 - frontiersin.org
pro-inflammatory cytokines were inhibited by local microinjection of the microglial inhibitor
minocycline… preparation; BZ and YD performed animal model and the data analyses; DG and …

1, 3, 4-Oxadiazole derivative attenuates chronic constriction injury induced neuropathic pain: a computational, behavioral, and molecular approach

M Faheem, SH Ali, AW Khan, M Alam, U Ilyas… - Brain Sciences, 2020 - mdpi.com
… and development of hyperalgesia and mechanical allodynia [23,24]… ASA, RU, and AMA
helped in laboratory facilitation, also … neuropathic pain using chronic constriction injury rat model

[HTML][HTML] Abnormalities in inflammatory cytokines confer susceptible to chronic neuropathic pain-related anhedonia in a rat model of spared nerve injury

X Fang, G Zhan, J Zhang, H Xu, B Zhu… - Clinical …, 2019 - ncbi.nlm.nih.gov
… Additionally, ketamine treatment significantly attenuated the … )-1β antagonist could exert
facilitating effects on depression.25) … pro-inflammatory cytokines TNF-α and IL-1β, but not IL-6, in …

[PDF][PDF] Spinal NF-kB upregulation contributes to hyperalgesia in a rat model of advanced

Y Li, Y Yang, J Guo, X Guo, Z Feng, X Zhao - source.ymvkt.cn
… of proinflammatory cytokines and induced the generation of … Descending serotonergic
facilitation and the antinociceptive … Minocycline attenuates bone cancer pain in rats by inhibiting NF…

Analgesic effect of voluntary exercise in a rat model of persistent pain via suppression of microglial activation in the spinal cord

R Takahara-Yamauchi, H Ikemoto, T Okumo… - Biomedical …, 2021 - jstage.jst.go.jp
… lin-induced persistent mechanical allodynia and hyperalgesia in rats are attenuated by …
activated to generate central sensitization by releasing proinflammatory cytokines. Iba1, a 17-kDa …

Astrocytic purinergic signalling contributes to the development and maintenance of neuropathic pain via modulation of glutamate release

S Liu, H Cheng, L Cui, L Jin, Y Li, C Zhu… - Journal of …, 2023 - Wiley Online Library
… However, administration of minocycline or etanercept distinctly … spinal dorsal horn contributes
to pain facilitation, which is in line … AMPK activation attenuates inflammatory pain through …

[HTML][HTML] … of p38MAPK in spinal microglia contributes to autologous nucleus pulposus-induced mechanical hyperalgesia in a modified rat model of lumbar disk …

YM Wang, FJ Gao, SQ Lin, ZX Yi, JM Zhang, HX Wu… - Brain Research, 2020 - Elsevier
rat model of non-compressive LDH successfully, and a pain … of mechanical hypersensitivity
in our modified rat model of non-… minocycline can effectively prevent NP-evoked radicular …