Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson's disease
C Nunes, J Laranjinha - Archives of Biochemistry and Biophysics, 2021 - Elsevier
… cell death via mechanisms that involve mitochondrial dysfunction, gluthathione depletion
and nitroxidative stress. … the neuronal death that occurs in the neurodegenerative diseases. …
and nitroxidative stress. … the neuronal death that occurs in the neurodegenerative diseases. …
Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease
SV Mangrulkar, NL Wankhede, MB Kale… - Neurotoxicity …, 2023 - Springer
… to target dysfunction of mitochondria in the treatment of neurodegenerative diseases, this
review … responses, spanning from energy generation to cell mortality. The careful regulation of …
review … responses, spanning from energy generation to cell mortality. The careful regulation of …
3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases
M Bandookwala, P Sengupta - International Journal of …, 2020 - Taylor & Francis
… mitochondrial dysfunction and Nrf2 in response to OS in the cytoplasm in sALS patients. Overall
data from … for TDP-43-mediated cell death through a mechanism yet not fully established […
data from … for TDP-43-mediated cell death through a mechanism yet not fully established […
Neurodegenerative diseases associated with mitochondrial DNA mutations
OA Zhunina, NG Yabbarov, AV Grechko… - Current …, 2020 - ingentaconnect.com
… Mitochondrial dysfunction and cell death in neurodegenerative diseases through
nitroxidative stress. Brain Res 2016; 1637: 34-55. http://dx.doi.org/10.1016/j.brainres.2016.02.016 …
nitroxidative stress. Brain Res 2016; 1637: 34-55. http://dx.doi.org/10.1016/j.brainres.2016.02.016 …
Fundamental mechanisms of the cell death caused by nitrosative stress
F Wang, Q Yuan, F Chen, J Pang, C Pan… - Frontiers in Cell and …, 2021 - frontiersin.org
… disorders affects cell death. This review focuses on the biochemistry of nitrosative stress, as
well as several new forms of cell death, and … , mitochondrial dysfunction, and cell membrane …
well as several new forms of cell death, and … , mitochondrial dysfunction, and cell membrane …
Dysfunctional Mitochondria in Age-related Neurodegeneration: Utility of Melatonin as an Antioxidant Treatment
… , neurodegenerative conditions are major factors that contribute to morbidity and mortality. …
Herein, we stress that the high levels of melatonin in the mitochondria are primarily due to its …
Herein, we stress that the high levels of melatonin in the mitochondria are primarily due to its …
… -Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders
S Rodkin, C Nwosu, A Sannikov, A Tyurin… - International Journal of …, 2023 - mdpi.com
… However, excess NO can be detrimental, causing cartilage degradation or inhibiting cartilage
matrix synthesis and causing mitochondrial dysfunction. There is a correlation between NO …
matrix synthesis and causing mitochondrial dysfunction. There is a correlation between NO …
Resveratrol: A potential therapeutic natural polyphenol for neurodegenerative diseases associated with mitochondrial dysfunction
… It showed that RES treatment to SH-SY5Y cells significantly prevented the cell death
initiated by rotenone via modulating autophagic induction and overall autophagic flux. Further …
initiated by rotenone via modulating autophagic induction and overall autophagic flux. Further …
The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide
… Moreover, mitochondrial dysfunction has been linked to various neurodegenerative diseases,
and … quality control (MQC); mitochondrial dysfunction can lead to cell death upon the …
and … quality control (MQC); mitochondrial dysfunction can lead to cell death upon the …
Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation
S Madireddy, S Madireddy - Brain sciences, 2023 - mdpi.com
… to an efflux of ions and mitochondrial molecules that ultimately cause cell death [73]. …
mitochondrial Ca 2+ levels have been observed during seizures [83]. An excess of mitochondrial …
mitochondrial Ca 2+ levels have been observed during seizures [83]. An excess of mitochondrial …