[HTML][HTML] Forging a functional cure for HIV: transcription regulators and inhibitors

S Mediouni, S Lyu, SM Schader, ST Valente - Viruses, 2022 - mdpi.com
… or either host transcriptional factors and chromatin regulators, … confirmed in primary cells
and resting CD4 + T cells from an … -κB in the nucleus increases its DNA-binding affinity. Several …

TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer

N Kaushik, A Jaiswal, P Bhartiya, EH Choi… - Cancer and Metastasis …, 2024 - Springer
… unusual DNA-binding activity, these transcription factors are … T lymphocytes, inducers of
cell growth can increase CP2's … The mitogenic stimulus binds TFCP2 to the essential promoter …

[HTML][HTML] Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells

SY Shin, MW Kim, KH Cho, LK Nguyen - Scientific Reports, 2019 - nature.com
… that amplified activation of the transcriptional factor NFAT in … function known as the logarithmic
sensitivity function (LSF). … affect the levels of mitogen-activated protein kinase signaling …

[HTML][HTML] HIV Expression in Infected T Cell Clones

JW Rausch, S Parvez, S Pathak, AA Capoferri… - Viruses, 2024 - mdpi.com
… upon host cell and viral transcription factors binding to an array … II transcription complexes,
CDK9-mediated phosphorylation … by DNA sequence, DNA binding proteins, and the activity of …

[PDF][PDF] critical role of the transcription factor Miz-1 in T cell activation and maturation

AS Mägdefrau - 2023 - db-thueringen.de
… These cells show a fast and efficient response to the … the linker for activation of T cells (LAT)
through phosphorylation, … of which are important for its DNA binding capacity. An important …

A cellular perspective of adipogenesis transcriptional regulation

W Kuri‐Harcuch, C Velez‐delValle… - Journal of cellular …, 2019 - Wiley Online Library
mitogenic effects. Adipose differentiation of the 3T3-F442A … examined the activity of the
transcription factors accepted as … bHLH protein to enhance DNA binding. It seemed logical to …

[HTML][HTML] Grainyhead-like 2 as a double-edged sword in development and cancer

…, C Feng, H Zhu, S Wu, P Jin, T Xu - American journal of …, 2020 - ncbi.nlm.nih.gov
… , the LSF subfamily including CP2, LBP-1a, and LBP-9 … GRHL transcription factors are
classified as DNA-binding … leading to activation of Smad2 and Smad3 by phosphorylation, p-…

Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat

M Taura, E Song, YC Ho… - Proceedings of the …, 2019 - National Acad Sciences
… in latently infected human primary CD4 T cells enhanced HIV-1 … In resting CD4 T cells, the
lack of active cellular transcription … knockdown enhanced NL4-3/Luc–derived luciferase activity

Steering molecular activity with optogenetics: recent advances and perspectives

TJ Oh, H Fan, SS Skeeters, K Zhang - Advanced biology, 2021 - Wiley Online Library
… domains to the promoter, controlling the transcription factor's … A common strategy to probe
the kinetic proofreading in T cells is … DNA-binding protein 43 kDa (optoTDP43) with CRY2olig …

[HTML][HTML] A specific peptide with immunomodulatory activity from Pseudostellaria heterophylla and the action mechanism

Q Yang, X Cai, M Huang, S Wang - Journal of Functional Foods, 2020 - Elsevier
T lymphocytes (T cells) and B lymphocytes (B cells) play … NF-κB is an important transcriptional
factor which can be … as a mitogen for murine spleen lymphocytes and could cause T