Production of L-carnitine-enriched edible filamentous fungal biomass through submerged cultivation

N Rousta, JA Ferreira, MJ Taherzadeh - Bioengineered, 2021 - Taylor & Francis
… , the increasing trend of L-carnitine continued up to 48 h and … In addition to cultivation
optimization and process scale-up using … needs also to be linked to in vitro digestion simulation

[HTML][HTML] Quantitative systems pharmacology Model to characterize valproic acid-induced hyperammonemia and the effect of L-carnitine supplementation

A Schiavo, C Maldonado, M Vázquez… - European Journal of …, 2023 - Elsevier
… -carnitine dose selection to optimize CS depending on VPA … Carnitine deficiency is also
produced by VPA-CAR-mediated inhibition of … The parametrization of continuous and categorical …

[HTML][HTML] … use of an in-vitro batch fermentation (human colon) model for investigating mechanisms of TMA production from choline, l-carnitine and related precursors …

…, B Nemeckova, J Speranza, L Kellingray… - European Journal of …, 2021 - Springer
… of choline started to decline between 6 and 8 h and continued to do so until 24 h by which
time it was almost completely utilised in all experiments (Fig. 3b). TMA levels started to …

[HTML][HTML] Assessing the in vitro and in vivo performance of L-carnitine-loaded nanoparticles in combating obesity

B Uner, AD Ergin, IA Ansari, MS Macit-Celebi… - Molecules, 2023 - mdpi.com
… design model, we optimized the … that carnitine could aid in red blood cell function or production.
To explore this, the study examined the effects of L-carnitine and palmitoyl-L-carnitine on …

A quality by design approach for the synthesis of palmitoyl-L-carnitine-loaded nanoemulsions as drug delivery systems

EM Arroyo-Urea, M Muñoz-Hernando… - Drug Delivery, 2023 - Taylor & Francis
… -L-carnitine (pC) as model molecule. Different types of … In the first optimization run we obtained
84 solutions, while … processes, such as nanoparticles production. After the first screening …

Effects of L-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis

Y Li, Y Xie, C Qiu, B Yu, F Yang, Y Cheng, W Zhong… - Food & Function, 2023 - pubs.rsc.org
… Meta-analysis was performed in a random effect model with … TC in L-carnitine supplementation,
which was continued for more … mainly produced by liver? A systematic review and meta-…

L-carnitine enhances developmental potential of bovine oocytes matured under high lipid concentrations in vitro

GD Catandi, MH Cheng, AJ Chicco, T Chen… - Animal Reproduction …, 2023 - Elsevier
… logistic regression model, incorporating replicates, treatments, and bulls. Continuous data
were … produced from oocytes exposed to L-carnitine during IVM (LC and HNLC) than in those …

[HTML][HTML] The effect of high-intensity interval training and l-carnitine on the expression of genes involved in lipid and glucose metabolism in the liver of wistar rats

B Shahouzehi, Y Masoumi-Ardakani… - Brazilian Archives of …, 2022 - SciELO Brasil
L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with …
When HIIT is continued the lactate production will no longer be at higher and will decrease over …

Exometabolome profiling reveals activation of the carnitine buffering pathway in fed‐batch cultures of CHO cells co‐fed with glucose and lactic acid

J Vappiani, T Eyster, K Orzechowski… - Biotechnology …, 2021 - Wiley Online Library
… for proper and continuous functioning of … production. At the same time, it was predicted that
upregulating pyruvate dehydrogenase and acetyl-CoA synthetase would lead to optimization

[HTML][HTML] Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production

…, SN Barile, P Scarcia, I Pisano, L Palmieri… - Microbial Cell …, 2023 - Springer
… work, we propose a model for metabolism and transport of acetyl groups among peroxisomes,
Experiments are ongoing to determine if the expression levels of this carrier can modulate …