… in conditions such as ischemic heart disease. Here, we used a modified mRNA (modRNA)
gene delivery platform to deliver a cocktail, termed 7G-modRNA, of four cardiac-…

… Endothelial cells and cardiovascular cells Mouse myocardial infarction model Modified
mRNA directs the fate of heart progenitor cells and induces vascular regeneration after …

… epicardial progenitor cells to differentiate into adipogenic cells, … can be used in future cardiac
regenerative applications. … the heart, but this direct gene penetration into the myocardium …

… of mRNA for stem cell generation or enhancement for the purpose of cardiovascular
regeneration. … The local increase in VEGFA induced the expansion and directed differentiation of …

… leads to the direct loss of a subset of mRNA transcripts due to … the survival and fate of
transplanted stromal cells in a similar … homing potential of hematopoietic progenitor cells to bone …

… into cardiac progenitor cells and subsequent differentiation, and (3) direct reprogramming
of … In the future, direct cardiac reprogramming technology may be used to discover effective …

… Even without direct cardiomyocyte regeneration, methods that promote … of modified RNA
(modRNA) of paracrine factors promotes heart function and drives heart progenitor cell fate. …

… for directed differentiation or trans-differentiation of stem/progenitor cells to defined cell …
we hope to inspire future investigations using cmRNAs for regenerative medicine in a timely …

… functional renewal is vital for effective heart regeneration [18]… CPCs from iPSCs and through
direct reprogramming. It will … to direct the mesodermal cells towards the cardiac fate [126]. …

… of organ size, cell proliferation, and stem cell fate determination. … to localize m 6 A-modified
mRNAs into decay sites and affect … When the cells reached ~60% confluence, we directed …