Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

NN Rieser, M Ronchetti, AL Hotz, SCF Neuhauss - bioRxiv, 2024 - biorxiv.org
… In acute PTZ exposure however, galanin modulated seizures significantly. While we
hypothesized to see antiepileptic effects upon modulation of galanin, our observations did not …

[HTML][HTML] Cortical spreading depolarization is a potential target for rat brain excitability modulation by Galanin

F Gimeno-Ferrer, A Eitner, R Bauer… - Experimental …, 2023 - Elsevier
… Pathological increases in brain cortical excitability play an important role in human central
nervous diseases ranging from epilepsy to migrainic headache. Excitability of nerve cells is …

[HTML][HTML] Galanin analogs prevent mortality from seizure-induced respiratory arrest in mice

R Collard, MC Aziz, K Rapp, C Cutshall… - Frontiers in Neural …, 2022 - frontiersin.org
… The amygdala is enriched in neuropeptides that modulate neuronal activity and can be …
seizures and downstream breathing control following seizures, and the depletion of galanin may …

Increased expression of galanin and its receptors in the dorsal hippocampus during epileptogenesis in a rat model of pilocarpine-induced temporal lobe epilepsy

J Sun, S Xu, X Li, T Li, C Liu, J Zhou, G Luan, Z Xu - Stress and Brain, 2023 - sciopen.com
… Meanwhile, galanin-positive cells appeared, while galanin-… in galanin synthesis and release
during the acute seizure phase… when attempting to pharmacologically modulate this system. …

Galanin Analogs Prevent Seizure-Induced Respiratory Arrest

R Collard, MC Aziz, K Rapp, C Cutshall, E Duyvesteyn… - bioRxiv, 2022 - biorxiv.org
… The amygdala is enriched in neuropeptides that modulate neuronal activity and … seizure
burden. Therefore, the purpose of this study is to use rodent models to demonstrate how galanin

[HTML][HTML] Galanin diminishes cortical spreading depolarization across rodents–A candidate for treatment?

F Gimeno-Ferrer, A Eitner, HG Schaible, F Richter - Neuroscience Letters, 2024 - Elsevier
… molecules and mediators that modulate CSD in order to … inhibitory effects in epilepsy and
CSDs. The role of Gal in … seems to be essential to control excitability as all cortical neurons in …

Alarin potentiates ongoing epileptiform activity in rat brain slices: an in vitro electrophysiological study

ÖF Kalkan, H Öztürk, Z Şahin, H Başoğlu… - Acta Neurobiologiae …, 2024 - ane.pl
… the galanin peptide family, we wanted to investigate the potential relevance of alarin in
epilepsy‑like conditions in hippocampal … In our study, alarin modulated 4AP‑induced epileptiform …

Advancements in neuroactive peptides in seizures

SM Janković, M Đešević - Expert Review of Neurotherapeutics, 2022 - Taylor & Francis
hippocampal interneurons that express cortistatin have a certain inhibitory role in the modulation
of neuronal excitability… expression of galanin in the piriform cortex, hippocampal dentate …

Neural networks in generalized epilepsy and novel antiepileptic drugs

FM Werner, R Coveñas - Current pharmaceutical design, 2019 - ingentaconnect.com
… An increased excitability occurs when the alteration of these … and neuropeptides (neuropeptide
Y, galanin, dynorphin) are … The importance of modulating neuropeptides such as galanin

[HTML][HTML] Insights into potential targets for therapeutic intervention in epilepsy

C Zavala-Tecuapetla, M Cuellar-Herrera… - International journal of …, 2020 - mdpi.com
… of neuronal excitability since its involvement in the modulation of … Galanin is a modulator
of classical neurotransmitters and is … galanin protection from seizures and seizure-induced …