… Development of an airway mucus defect in the cystic fibrosis rat. JCI Insight. 2018;3(1):…
Molecular basis for pHdependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad …

… Chloride secretion mainly involves the cystic fibrosis … the epithelium against dehydration
and bathes the cilia [29]. … the pH-dependent color changes of organic dye molecules (…

… the cellular and molecular mechanisms that control pH ASL . … an airway phenotype marked
by thick, adherent mucus and … viruses into airway epithelial cells (eg, pH-dependent entry of …

… , with prolonged time of contact and continuous reseeding from infected mucus plugs. It is …
that this impaired host defense is pH-dependent. Increasing CF ASL pH improved its …

… mechanisms derange the ion transport pathways that normally hydrate mucus in muco-obstructive
lung diseases, eg, cystic fibrosis … prevent dehydration by the osmotically active mucus …

… entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in
lung function due to thick mucus … Molecular basis for pH- dependent mucosal dehydration in …

… airway surface liquid pH, viscosity, and antibacterial activity in primary cultures of airway
epithelia from people with cystic fibrosis … yield CFTR, and increased airway surface liquid pH in …

… Cystic fibrosis (CF) is characterized by increased mucus viscosity and delayed … Mucus in
the respiratory and GI tract is excessively adhesive in the presence of airway dehydration and …

… Cystic fibrosis (CF) is a recessive genetic disease caused by … This bactericidal activity of
sphingosine itself is also pH dependent … Airway obstruction in CF is due to mucus dehydration/…

… cystic fibrosis (CF), loss of CFTR chloride channel function causes airway surface dehydration…
activity of antimicrobial molecules and alter the properties and the release of mucus (13–16…