Molecular profiling of neuroendocrine tumours to predict response and toxicity to peptide receptor radionuclide therapy

L Bodei, H Schöder, RP Baum, K Herrmann… - The lancet …, 2020 - thelancet.com
… No molecular markers exist that can predict the toxicity of PRRT. Candidate molecular
are tumour-specific, might yield molecular tools to enhance the efficacy and safety of PRRT. …

Pancreatic cancer: a review of current treatment and novel therapies

HM Kolbeinsson, S Chandana, GP Wright… - Journal of Investigative …, 2023 - Taylor & Francis
… In summary, pancreatic cancer remains a disease with poor long-… pancreatic cancer
treatment and the milestones that brought us to where we are today, along with emerging therapies

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

L Cheng, J Wang, H Dai, Y Duan, Y An, L Shi, Y Lv… - Adipocyte, 2021 - Taylor & Francis
therapeutic effect of these drugs is not as expected. Therefore, it is necessary to find a novel
therapy … insulin sensitivity, reduce weight and maintain the activity of pancreatic beta cells. …

Current and novel therapeutic opportunities for systemic therapy in biliary cancer

JJG Marin, MG Prete, A Lamarca, S Tavolari… - … journal of cancer, 2020 - nature.com
therapies, active research avenues explore the development of novel therapeutics that target
the crosstalk between cancer and … In this review, we discuss the therapeutic opportunities …

Heart failure in type 2 diabetes mellitus: impact of glucose-lowering agents, heart failure therapies, and novel therapeutic strategies

HC Kenny, ED Abel - Circulation research, 2019 - Am Heart Assoc
… Inhibition of SGLT2 promotes glycosuria and represents a novel therapeutic strategy for
treating T2DM. Three SGLT2i are currently in clinical use; dapagliflozin, canagliflozin, and …

[HTML][HTML] A review on curability of cancers: more efforts for novel therapeutic options are needed

S Wang, Y Liu, Y Feng, J Zhang, J Swinnen, Y Li, Y Ni - Cancers, 2019 - mdpi.com
cancer as regards to different therapies and cancer types. Finally, we propose a small molecule
dual-targeting broad-spectrum anticancer strategy … , especially at the micro-cancer stage. …

[HTML][HTML] Cancer-associated fibroblasts: mechanisms of tumor progression and novel therapeutic targets

RP Czekay, DJ Cheon, R Samarakoon, SM Kutz… - Cancers, 2022 - mdpi.com
tumor survival [79]. Clarifying the impact of the dynamic CAF environment on tumor growth
and metastasis may inform novel treatment strategies targeting specific CAF populations. …

Comprehensive genomic profiling of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs)

A Puccini, K Poorman, ME Salem, D Soldato… - Clinical Cancer …, 2020 - AACR
… of PR expression, we observed that HG tumors, which have a worse prognosis, … endocrine
therapy in breast and other cancers, thus our findings may lead to a novel treatment strategy

[HTML][HTML] Breast cancer heterogeneity and response to novel therapeutics

M Baliu-Piqué, A Pandiella, A Ocana - Cancers, 2020 - mdpi.com
cancer is a heterogeneous disease that is driven by genetic, … article we review genetic and
non-genetic causes of tumor … heterogeneity has on resistance to therapy. We will provide …

[HTML][HTML] Homogeneous MMR deficiency throughout the entire tumor mass occurs in a subset of colorectal neuroendocrine carcinomas

C Fraune, R Simon, C Hube-Magg… - Endocrine …, 2020 - Springer
… , demanding novel treatment strategies such as immune checkpoint inhibition in tumors with
… of 10) but highly infrequent in neuroendocrine neoplasms from many other sites. The lack of …