Molecular profiling of neuroendocrine tumours to predict response and toxicity to peptide receptor radionuclide therapy
… No molecular markers exist that can predict the toxicity of PRRT. Candidate molecular …
are tumour-specific, might yield molecular tools to enhance the efficacy and safety of PRRT. …
are tumour-specific, might yield molecular tools to enhance the efficacy and safety of PRRT. …
Pancreatic cancer: a review of current treatment and novel therapies
HM Kolbeinsson, S Chandana, GP Wright… - Journal of Investigative …, 2023 - Taylor & Francis
… In summary, pancreatic cancer remains a disease with poor long-… pancreatic cancer
treatment and the milestones that brought us to where we are today, along with emerging therapies…
treatment and the milestones that brought us to where we are today, along with emerging therapies…
Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus
L Cheng, J Wang, H Dai, Y Duan, Y An, L Shi, Y Lv… - Adipocyte, 2021 - Taylor & Francis
… therapeutic effect of these drugs is not as expected. Therefore, it is necessary to find a novel
therapy … insulin sensitivity, reduce weight and maintain the activity of pancreatic beta cells. …
therapy … insulin sensitivity, reduce weight and maintain the activity of pancreatic beta cells. …
Current and novel therapeutic opportunities for systemic therapy in biliary cancer
JJG Marin, MG Prete, A Lamarca, S Tavolari… - … journal of cancer, 2020 - nature.com
… therapies, active research avenues explore the development of novel therapeutics that target
the crosstalk between cancer and … In this review, we discuss the therapeutic opportunities …
the crosstalk between cancer and … In this review, we discuss the therapeutic opportunities …
Heart failure in type 2 diabetes mellitus: impact of glucose-lowering agents, heart failure therapies, and novel therapeutic strategies
HC Kenny, ED Abel - Circulation research, 2019 - Am Heart Assoc
… Inhibition of SGLT2 promotes glycosuria and represents a novel therapeutic strategy for
treating T2DM. Three SGLT2i are currently in clinical use; dapagliflozin, canagliflozin, and …
treating T2DM. Three SGLT2i are currently in clinical use; dapagliflozin, canagliflozin, and …
[HTML][HTML] A review on curability of cancers: more efforts for novel therapeutic options are needed
… cancer as regards to different therapies and cancer types. Finally, we propose a small molecule
dual-targeting broad-spectrum anticancer strategy … , especially at the micro-cancer stage. …
dual-targeting broad-spectrum anticancer strategy … , especially at the micro-cancer stage. …
[HTML][HTML] Cancer-associated fibroblasts: mechanisms of tumor progression and novel therapeutic targets
RP Czekay, DJ Cheon, R Samarakoon, SM Kutz… - Cancers, 2022 - mdpi.com
… tumor survival [79]. Clarifying the impact of the dynamic CAF environment on tumor growth
and metastasis may inform novel treatment strategies targeting specific CAF populations. …
and metastasis may inform novel treatment strategies targeting specific CAF populations. …
Comprehensive genomic profiling of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs)
… of PR expression, we observed that HG tumors, which have a worse prognosis, … endocrine
therapy in breast and other cancers, thus our findings may lead to a novel treatment strategy …
therapy in breast and other cancers, thus our findings may lead to a novel treatment strategy …
[HTML][HTML] Breast cancer heterogeneity and response to novel therapeutics
M Baliu-Piqué, A Pandiella, A Ocana - Cancers, 2020 - mdpi.com
… cancer is a heterogeneous disease that is driven by genetic, … article we review genetic and
non-genetic causes of tumor … heterogeneity has on resistance to therapy. We will provide …
non-genetic causes of tumor … heterogeneity has on resistance to therapy. We will provide …
[HTML][HTML] Homogeneous MMR deficiency throughout the entire tumor mass occurs in a subset of colorectal neuroendocrine carcinomas
C Fraune, R Simon, C Hube-Magg… - Endocrine …, 2020 - Springer
… , demanding novel treatment strategies such as immune checkpoint inhibition in tumors with
… of 10) but highly infrequent in neuroendocrine neoplasms from many other sites. The lack of …
… of 10) but highly infrequent in neuroendocrine neoplasms from many other sites. The lack of …