… cancer is a heterogeneous disease that is driven by genetic, … article we review genetic and
non-genetic causes of tumor … heterogeneity has on resistance to therapy. We will provide …

… , demanding novel treatment strategies such as immune checkpoint inhibition in tumors with
… of 10) but highly infrequent in neuroendocrine neoplasms from many other sites. The lack of …

… of Cancer Stem Cells (CSCs). Furthermore, we have summarized the … strategies used to
target aberrant Wnt signaling as a novel therapeutic intervention to combat various cancers …

… Hence, molecular markers have become a potent tool also in TC management to … as for
identification of novel therapeutic targets. In differentiated TC, molecular markers are mainly used …

… OCSCs markers and their meaning both for cancer biology … activated in OCSCs, the genetic
and epigenetic regulation of … a novel approach to ovarian cancer diagnosis and therapy. …

… ; therefore, targeting vascular IGF-I resistance may represent a novel therapeutic target to
prevent or slow the accelerated vascular disease seen in patients with obesity or T2DM [39]. …

… This review article describes EC heterogeneity and heterogeneous tumor-associated ECs
(… therapy in pNETs and discuss the potential of tumor arteriogenesis as a novel therapeutic …

… -cell lung cancer), the majority of such single genetic marker … for pancreatic cancer, as current
treatment approaches for … excluded from studies so that novel therapies are not tested for …

… neuroendocrine neoplasms; however, the remaining biological factors are undetermined.
Rapid advances in molecular diagnostic and treatment strategies in … a novel therapeutic target. …

… This review summarizes the current knowledge of structural features of LGALS3BP, its
pattern of expression in cancer and the potential role as novel therapeutic target in cancer. …