… state typically associated with ageing and degeneration, is … fibroblasts that release pro-inflammatory
mediators (such as TNF, … Thus, chondrocytes rely on unique molecular mechanisms, …

… Among the most frequent risk factors identified are age, joint … A considerable increase in
the synthesis of mediator molecules… of molecules aggravates the damage of the cartilage and …

… to be involved in age-related cartilage degeneration in OA. … participate in the molecular
mechanisms of arthritic conditions… shown to target pro-inflammatory mediators, particularly those …

… of repair molecules to the site of collagen fibril damage from the tissue … We note that for
cartilage tissue, mechanical loading is … Importantly some research is pointing to age-dependent …

… articular cartilage destruction, is the most common form of age-… Although OA is primarily
characterized by cartilage destruction… To investigate the molecular mechanisms that regulate the …

… leading causes of disability in elderly population. Today, we … , causing cartilage damage,
while cartilage matrix catabolism … Endogenous molecular mechanisms that down-regulate the …

… in the context of joint aging and osteoarthritis. We also aimed … This was proposed as a possible
source of cartilage damage … Hence, the cellular and molecular mechanisms behind such …

… to interrogate molecular mechanisms driving age-related … OA through mechanical, catabolic,
and inflammatory mediators(… HCD fragmentation was performed with collision energy of 32…

… chondrocytes autophagy and induces cartilage degeneration during osteoarthritis [52], and
… cellular matrix, which gives the articular cartilage its mechanical integrity for the daily load-…

… cartilage damage and joint space narrowing. As a result of the increased damage the cartilage
… synovium leading to synovial inflammation as well as damage to the bone underlying the …