… addictive drugs induce transcriptomic plasticity in addiction-… in the mechanisms through which
addictive drugs act in the brain… of the molecular mechanisms through which drugs of abuse …

… drug-induced changes in gene expression that drive the transition … addiction. We conclude
by exploring how epigenetic mechanisms might serve as therapeutic targets for addiction …

… , effectively model several aspects of drug addiction. We conclude by outlining what next
steps should be taken to advance our understanding in hopes of fighting the opioid epidemic. …

… The current study provides a comprehensive scientific exploration of the molecular
mechanisms and underlying signalling in morphine tolerance and dependence. It also critically …

… the molecular targets and the molecular mechanisms involved in these effects. Structural
details from experimental structures of the ligand-binding sites are also discussed, along with …

… addiction, we hypothesize the use of ketamine as an antidepressant activates neural pathways
and mechanisms closely implicated in drug addiction, … involved in drug addiction, and are …

… Cloning GABA B opened up a venue for studying molecular mechanisms of its function, …
), shedding light on its molecular mechanisms of signal transduction across the membrane. …

… deaths) (58) use, highlights the devastating impact of drugs and addiction in our society. …
underpinnings of drug reinforcement and addiction. As a result, addiction, which has been …

… (GPCRs), however, the molecular mechanisms of ligand-specific signaling at … molecular
determinants of KOR signaling bias, we apply structure determination, atomic-level molecular …

… The present review summarized the underlying molecular mechanisms of opioid tolerance
facilitated by both within-system and between-system regulation. Agonist activation results in …