Monitoring of minimal residual disease (MRD) in chronic myeloid leukemia: recent advances

C Cumbo, L Anelli, G Specchia… - Cancer management and …, 2020 - Taylor & Francis
… method for monitoring CML minimal residual disease (MRD) and the optimal CML patient
crucial aspects of CML patients molecular monitoring. Citation20 In the past years, RQ-PCR …

[HTML][HTML] Monitoring chronic myeloid leukemia: how molecular tools may drive therapeutic approaches

B Izzo, EM Gottardi, S Errichiello, F Daraio… - Frontiers in …, 2019 - frontiersin.org
… the residual disease were discussed and presented, with the purpose of rapidly expanding
the importance of the molecular monitoring of … role of the molecular response was evident, the …

[HTML][HTML] Measurable residual disease in chronic myeloid leukemia

S Branford, JF Apperley - Haematologica, 2022 - ncbi.nlm.nih.gov
… the integration of molecular monitoring with other factors that affect patients’ management, …
residual disease during treatment. Measurable residual disease in chronic myeloid leukemia

[HTML][HTML] Why is it critical to achieve a deep molecular response in chronic myeloid leukemia?

S Branford - Haematologica, 2020 - ncbi.nlm.nih.gov
… kinase inhibitor (TKI) therapy for patients with chronic myeloid leukemia is survival, which
is … The method was used to measure residual disease in a substantial proportion of patients

[HTML][HTML] Novel Multiplex Droplet Digital PCR Assays to Monitor Minimal Residual Disease in Chronic Myeloid Leukemia Patients Showing Atypical BCR-ABL1 …

J Petiti, M Lo Iacono, M Dragani, L Pironi… - Journal of clinical …, 2020 - mdpi.com
… good candidates for treatment-free remission … promising molecular approach, highly sensitive,
to monitor atypical BCR–ABL1 patients, paving the foundation to include them in treatment-…

[HTML][HTML] … disease monitoring provides insufficient lead-time to prevent morphological relapse in the majority of patients with core-binding factor acute myeloid leukemia

R Puckrin, EG Atenafu, JO Claudio, S Chan… - …, 2021 - ncbi.nlm.nih.gov
… (MRD), defined as the presence of leukemic cells after treatment at … Molecular monitoring for
MRD is well-established in … defined disease markers, such as BCR-ABL1 in chronic myeloid

Standardization of molecular monitoring for chronic myeloid leukemia: 2021 update

M Salmon, HE White, NCP Cross… - … Myeloid Leukemia, 2021 - Springer
therapy in patients with chronic myeloid leukemia and is used to define time-related clinical
milestones as well as eligibility for stopping treatment… of residual disease in acute leukemia, …

[HTML][HTML] Assessing Measurable Residual Disease in Chronic Myeloid Leukemia. BCR-ABL1 IS in the Avant-Garde of Molecular Hematology

V Moisoiu, P Teodorescu, L Parajdi, S Pasca… - Frontiers in …, 2019 - frontiersin.org
… with the continuous improvement in the therapeutic arsenal against CML, the molecular
monitoring of CML represents the avant-garde in the struggle to make CML a curable disease. …

[HTML][HTML] … stem cell (LSC) levels: comparison of RT-qPCR, d-PCR and CD26+ stem cell measurements in chronic myeloid leukemia (CML) patients in deep molecular …

E Abruzzese, M Bocchia, MM Trawinska, D Raspadori… - Cancers, 2023 - mdpi.com
… A Deep Molecular Response (DMR), defined as a BCR::ABL1 … of treatment among patients
with Chronic Myeloid Leukemia (CML). However, approximately 50% of patients in Treatment-…

Late molecular recurrences in patients with chronic myeloid leukemia experiencing treatment-free remission

P Rousselot, C Loiseau, M Delord, JM Cayuela… - Blood …, 2020 - ashpublications.org
… We previously described TFR patients with fluctuating values of minimal residual disease
(MRD) below the threshold of MMR. In accordance with our previous definition (at least 2 …