The graft versus leukemia effect: Donor lymphocyte infusions and cellular therapy

K Maurer, JH Antin - Frontiers in Immunology, 2024 - frontiersin.org
… of one patient treated with DLI for post-HSCT relapsed CML … DLI and may be an effective
therapy for molecular relapse of … DLI with interferon appears to be effective in CML (66), though …

Donor Lymphocyte Infusion

SK Sharma - Basics of Hematopoietic Stem Cell Transplant, 2023 - Springer
… of DLI, patients with graft failure or disease relapse only had … an adequate density of MHC
molecules on the cell surface, as … control post-SCT viral infections involved the infusion of DLI

Relapse Post Allogeneic Stem Cell Transplant

SK Sharma - Basics of Hematopoietic Stem Cell Transplant, 2023 - Springer
… the relapse including the persistence of disease at the molecularInterferon-alpha (IFN-a)
exerts a strong immunomodulatory … post SCT due to the alloreactive T cells in the DLI [6]. This …

Post‐hematopoietic stem cell transplantation relapse: Role of checkpoint inhibitors

E Roshandel, F Tavakoli, S Parkhideh… - Health Science …, 2022 - Wiley Online Library
… of immune response by overexpressing inhibitory molecules to … that this medication induces
upregulation of IFN-gamma. In a … tried for some post-SCT relapsed hematological disorders. …

Immunopathogenic mechanisms and modulatory approaches to graft-versus-host disease prevention in acute myeloid leukaemia

Y Pang, NG Holtzman - Best Practice & Research Clinical Haematology, 2023 - Elsevier
… adverse clinical, cytogenetic or molecular risk factors [5,6]. … GvHD prophylactic therapy and
relapse-prevention/treatment … They produce inflammatory cytokines such as interferon(IFN)-…

Management of relapsed cutaneous T‐Cell lymphoma following allogeneic hematopoietic stem cell transplantation: Review with representative patient case

DM Weiner, DJ Lewis, NG Spaccarelli… - … Therapy, 2022 - Wiley Online Library
… following SCT (post-SCT relapse). Testing of her peripheral … but did surprisingly respond to
low-dose interferon alpha and ECP… Relapse was less likely to occur in patients with molecular

Principles and Applications of Cellular Therapy in the Setting of Hematopoietic Cell Transplant

M Khan, R Siddiqi, EJ Shpall, A Olson - Hematopoietic Cell Transplantation …, 2019 - Elsevier
… to prevent or treat CMV reactivation in post-SCT patients. Alternatively, … DLI (with or without
interferon-alpha) in a variety of patient populations and malignancies with post-SCT relapse

Subclonal evolution of chronic lymphocytic leukemia after allogeneic T cell therapies

H Garber - 2020 - digitalcommons.library.tmc.edu
… Our cohort included 11 patients who relapsed after alloSCT, … ) and the asterisk denotes the
post-SCT CLL sample where the … To identify molecular predictors of transplant response, we …

Immune-Based Therapeutic Interventions for Acute Myeloid Leukemia

F Perna, MR Espinoza-Gutarra, G Bombaci… - … : Solid Tumors and …, 2022 - Springer
… in both the AML relapsed/refractory (R/R) and post SCT settings. … , PD-L1 overexpression on
T cells, release of IFN-γ, TNF-α, IL-2, IL-10… Another CD123 targeting molecule is IMGN632, a …

New approaches in allogenic transplantation in AML

X Pei, X Huang - Seminars in Hematology, 2019 - Elsevier
… and stratified patients by molecular response to chemotherapy… relapse early (<6 months
post-SCT), and the management of … to prevent AML relapse either using MRD-directed DLI, IFN-α…