Metabolic reprogramming in cancer cells: emerging molecular mechanisms and novel therapeutic approaches
… adaptation through their participation in multiple signaling … with the jun N-terminal kinase
(JNK) pathway, in parallel and … a nexus that unifies different signaling pathways and cellular …
(JNK) pathway, in parallel and … a nexus that unifies different signaling pathways and cellular …
Systemic analysis of tyrosine kinase signaling reveals a common adaptive response program in a HER2-positive breast cancer
… This transient nature of signaling inhibition revealed the control function of … same pathway
(10, 11) or of alternate signaling pathways that compensate for the perturbation by the inhibitor …
(10, 11) or of alternate signaling pathways that compensate for the perturbation by the inhibitor …
[HTML][HTML] Lipid metabolic reprogramming as an emerging mechanism of resistance to kinase inhibitors in breast cancer
WW Feng, M Kurokawa - Cancer Drug Resistance, 2020 - ncbi.nlm.nih.gov
… , as well as adaptation to metabolic stress such as glucose deprivation and hypoxia [145] .
… lipid metabolic reprogramming. The interconnectedness of signaling pathways that control …
… lipid metabolic reprogramming. The interconnectedness of signaling pathways that control …
Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRASG12C Inhibition
MB Ryan, F Fece de la Cruz, S Phat, DT Myers… - Clinical cancer …, 2020 - AACR
… by the MAPK pathway, leading to receptor tyrosine kinase (RTK)-… SHP2 inhibition can
abrogate adaptive feedback reactivation of RAS pathway signaling following KRAS G12C inhibition…
abrogate adaptive feedback reactivation of RAS pathway signaling following KRAS G12C inhibition…
Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
… of the targeted molecule, allowing cell survival. In normal cells, signalling … from adaptive
signalling rewiring can be targeted by blocking bypass pathways or inhibiting redundant kinase …
signalling rewiring can be targeted by blocking bypass pathways or inhibiting redundant kinase …
[HTML][HTML] Integrated molecular signaling involving mitochondrial dysfunction and alteration of cell metabolism induced by tyrosine kinase inhibitors in cancer
MA Rodríguez-Hernández, P de la Cruz-Ojeda… - Redox Biology, 2020 - Elsevier
… -activated protein kinase (AMPK) signaling pathways that involve cell metabolism reprogramming
in cancer … Ca 2+ signaling might play a crucial role in the adaptive resistance to EGFR …
in cancer … Ca 2+ signaling might play a crucial role in the adaptive resistance to EGFR …
Metabolic reprogramming in cancer: Mechanisms and therapeutics
S Nong, X Han, Y Xiang, Y Qian, Y Wei, T Zhang… - MedComm, 2023 - Wiley Online Library
… protein kinase that mediates the PI3K signaling pathway. … matrix structure, immune response,
angiogenesis, metastasis … the main adaptive changes in tumor metabolic reprogramming …
angiogenesis, metastasis … the main adaptive changes in tumor metabolic reprogramming …
Adaptation of human iPSC-derived cardiomyocytes to tyrosine kinase inhibitors reduces acute cardiotoxicity via metabolic reprogramming
… In this study, we profiled phenotypic and molecular responses to four widely used TKIs (sunitinib,
sorafenib, lapatinib, and erlotinib) in human induced pluripotent stem cell-derived CMs (…
sorafenib, lapatinib, and erlotinib) in human induced pluripotent stem cell-derived CMs (…
Metabolic reprogramming of chemoresistant cancer cells and the potential significance of metabolic regulation in the reversal of cancer chemoresistance
X Chen, S Chen, D Yu - Metabolites, 2020 - mdpi.com
… phosphate pathway, adaptive mitochondrial reprogramming, … of the tumor-driving signaling
pathway. General mechanisms, … Sorafenib is a tyrosine kinase inhibitor. Metabolism in …
pathway. General mechanisms, … Sorafenib is a tyrosine kinase inhibitor. Metabolism in …
Targeting hypoxia-driven metabolic reprogramming to constrain tumor progression and metastasis
M Miranda-Galvis, Y Teng - International journal of molecular sciences, 2020 - mdpi.com
… the master molecular regulators in the adaptive responses to … role played by the kinase
mammalian target of rapamycin (… and discovered the signaling pathways involved in the cancer …
mammalian target of rapamycin (… and discovered the signaling pathways involved in the cancer …